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Potent Anti-HIV Ingenane Diterpenoids from Euphorbia ebracteolata.

Publication ,  Journal Article
Huang, Y-S; Lu, Y; Chen, C-H; Lee, K-H; Chen, D-F
Published in: J Nat Prod
June 28, 2019

Two new (1 and 2) and 14 known (3-16) ingenane diterpenoids were isolated from the roots of Euphorbia ebracteolata by bioassay-guided fractionation together with UPLC-MS n analysis. The absolute configurations of the new diterpenoids were established from electronic circular dichroism (ECD) data and ECD calculations. Except for ingenol (16), the ingenane diterpenoids with long aliphatic chain substituents (1-15) exhibited potent activities against HIV-1, with IC50 values of 0.7 to 9.7 nM and selectivity index values of 96.2 to 20 263. From the results, it was concluded that long aliphatic chain substituents are required for the enhanced anti-HIV activity of ingenane diterpenoids.

Duke Scholars

Published In

J Nat Prod

DOI

EISSN

1520-6025

Publication Date

June 28, 2019

Volume

82

Issue

6

Start / End Page

1587 / 1592

Location

United States

Related Subject Headings

  • Structure-Activity Relationship
  • Plant Roots
  • Medicinal & Biomolecular Chemistry
  • Humans
  • HIV Infections
  • Euphorbia
  • Diterpenes
  • Chromatography, Liquid
  • Anti-HIV Agents
  • 4208 Traditional, complementary and integrative medicine
 

Citation

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MLA
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Huang, Y.-S., Lu, Y., Chen, C.-H., Lee, K.-H., & Chen, D.-F. (2019). Potent Anti-HIV Ingenane Diterpenoids from Euphorbia ebracteolata. J Nat Prod, 82(6), 1587–1592. https://doi.org/10.1021/acs.jnatprod.9b00088
Huang, Ya-Si, Yan Lu, Chin-Ho Chen, Kuo-Hsiung Lee, and Dao-Feng Chen. “Potent Anti-HIV Ingenane Diterpenoids from Euphorbia ebracteolata.J Nat Prod 82, no. 6 (June 28, 2019): 1587–92. https://doi.org/10.1021/acs.jnatprod.9b00088.
Huang Y-S, Lu Y, Chen C-H, Lee K-H, Chen D-F. Potent Anti-HIV Ingenane Diterpenoids from Euphorbia ebracteolata. J Nat Prod. 2019 Jun 28;82(6):1587–92.
Huang, Ya-Si, et al. “Potent Anti-HIV Ingenane Diterpenoids from Euphorbia ebracteolata.J Nat Prod, vol. 82, no. 6, June 2019, pp. 1587–92. Pubmed, doi:10.1021/acs.jnatprod.9b00088.
Huang Y-S, Lu Y, Chen C-H, Lee K-H, Chen D-F. Potent Anti-HIV Ingenane Diterpenoids from Euphorbia ebracteolata. J Nat Prod. 2019 Jun 28;82(6):1587–1592.
Journal cover image

Published In

J Nat Prod

DOI

EISSN

1520-6025

Publication Date

June 28, 2019

Volume

82

Issue

6

Start / End Page

1587 / 1592

Location

United States

Related Subject Headings

  • Structure-Activity Relationship
  • Plant Roots
  • Medicinal & Biomolecular Chemistry
  • Humans
  • HIV Infections
  • Euphorbia
  • Diterpenes
  • Chromatography, Liquid
  • Anti-HIV Agents
  • 4208 Traditional, complementary and integrative medicine