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Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women.

Publication ,  Journal Article
Martinez, DR; Fong, Y; Li, SH; Yang, F; Jennewein, MF; Weiner, JA; Harrell, EA; Mangold, JF; Goswami, R; Seage, GR; Alter, G; Ackerman, ME ...
Published in: Cell
June 27, 2019

The placental transfer of maternal IgG is critical for infant protection against infectious pathogens. However, factors that modulate the placental transfer of IgG remain largely undefined. HIV-infected women have impaired placental IgG transfer, presenting a unique "disruption model" to define factors that modulate placental IgG transfer. We measured the placental transfer efficiency of maternal HIV and pathogen-specific IgG in US and Malawian HIV-infected mothers and their HIV-exposed uninfected and infected infants. We examined the role of maternal HIV disease progression, infant factors, placental Fc receptor expression, IgG subclass, and glycan signatures and their association with placental IgG transfer efficiency. Maternal IgG characteristics, such as binding to placentally expressed Fc receptors FcγRIIa and FcγRIIIa, and Fc region glycan profiles were associated with placental IgG transfer efficiency. Our findings suggest that Fc region characteristics modulate the selective placental transfer of IgG, with implications for maternal vaccine design and infant health.

Duke Scholars

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Published In

Cell

DOI

EISSN

1097-4172

Publication Date

June 27, 2019

Volume

178

Issue

1

Start / End Page

190 / 201.e11

Location

United States

Related Subject Headings

  • Viral Load
  • United States
  • Receptors, IgG
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Placenta
  • Malawi
  • Infectious Disease Transmission, Vertical
  • Infant, Newborn
  • Infant
 

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Martinez, D. R., Fong, Y., Li, S. H., Yang, F., Jennewein, M. F., Weiner, J. A., … Permar, S. R. (2019). Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women. Cell, 178(1), 190-201.e11. https://doi.org/10.1016/j.cell.2019.05.046
Martinez, David R., Youyi Fong, Shuk Hang Li, Fang Yang, Madeleine F. Jennewein, Joshua A. Weiner, Erin A. Harrell, et al. “Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women.Cell 178, no. 1 (June 27, 2019): 190-201.e11. https://doi.org/10.1016/j.cell.2019.05.046.
Martinez DR, Fong Y, Li SH, Yang F, Jennewein MF, Weiner JA, et al. Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women. Cell. 2019 Jun 27;178(1):190-201.e11.
Martinez, David R., et al. “Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women.Cell, vol. 178, no. 1, June 2019, pp. 190-201.e11. Pubmed, doi:10.1016/j.cell.2019.05.046.
Martinez DR, Fong Y, Li SH, Yang F, Jennewein MF, Weiner JA, Harrell EA, Mangold JF, Goswami R, Seage GR, Alter G, Ackerman ME, Peng X, Fouda GG, Permar SR. Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women. Cell. 2019 Jun 27;178(1):190-201.e11.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

June 27, 2019

Volume

178

Issue

1

Start / End Page

190 / 201.e11

Location

United States

Related Subject Headings

  • Viral Load
  • United States
  • Receptors, IgG
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Placenta
  • Malawi
  • Infectious Disease Transmission, Vertical
  • Infant, Newborn
  • Infant