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Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns.

Publication ,  Journal Article
Shetty, AC; Jacob, CG; Huang, F; Li, Y; Agrawal, S; Saunders, DL; Lon, C; Fukuda, MM; Ringwald, P; Ashley, EA; Han, KT; Hlaing, TM; Nyunt, MM ...
Published in: Nature communications
June 2019

Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing of larger IBD segments between artemisinin-resistant parasites versus sensitive parasites, which is consistent with the recent spread of drug resistance. Our IBD analyses reveal actionable patterns, including isolated parasite populations, which may be prioritized for malaria elimination, as well as asymmetrical migration identifying potential sources and sinks of migrating parasites.

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Published In

Nature communications

DOI

EISSN

2041-1723

ISSN

2041-1723

Publication Date

June 2019

Volume

10

Issue

1

Start / End Page

2665

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Plasmodium falciparum
  • Malaria, Falciparum
  • Geography, Medical
  • Genotype
  • Genome, Protozoan
  • Epidemiological Monitoring
  • Drug Resistance
  • Biodiversity
  • Asia, Southeastern
 

Citation

APA
Chicago
ICMJE
MLA
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Shetty, A. C., Jacob, C. G., Huang, F., Li, Y., Agrawal, S., Saunders, D. L., … Tracking Resistance to Artemisinin Collaboration (TRAC), . (2019). Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns. Nature Communications, 10(1), 2665. https://doi.org/10.1038/s41467-019-10121-3
Shetty, Amol C., Christopher G. Jacob, Fang Huang, Yao Li, Sonia Agrawal, David L. Saunders, Chanthap Lon, et al. “Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns.Nature Communications 10, no. 1 (June 2019): 2665. https://doi.org/10.1038/s41467-019-10121-3.
Shetty AC, Jacob CG, Huang F, Li Y, Agrawal S, Saunders DL, et al. Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns. Nature communications. 2019 Jun;10(1):2665.
Shetty, Amol C., et al. “Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns.Nature Communications, vol. 10, no. 1, June 2019, p. 2665. Epmc, doi:10.1038/s41467-019-10121-3.
Shetty AC, Jacob CG, Huang F, Li Y, Agrawal S, Saunders DL, Lon C, Fukuda MM, Ringwald P, Ashley EA, Han KT, Hlaing TM, Nyunt MM, Silva JC, Stewart KE, Plowe CV, O’Connor TD, Takala-Harrison S, Artemisinin Resistance Confirmation, Characterization, and Containment (ARC3), Artemisinin Resistance Containment and Elimination (ARCE), Tracking Resistance to Artemisinin Collaboration (TRAC). Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns. Nature communications. 2019 Jun;10(1):2665.

Published In

Nature communications

DOI

EISSN

2041-1723

ISSN

2041-1723

Publication Date

June 2019

Volume

10

Issue

1

Start / End Page

2665

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Plasmodium falciparum
  • Malaria, Falciparum
  • Geography, Medical
  • Genotype
  • Genome, Protozoan
  • Epidemiological Monitoring
  • Drug Resistance
  • Biodiversity
  • Asia, Southeastern