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The roles of structural dynamics in the cellular functions of RNAs.

Publication ,  Journal Article
Ganser, LR; Kelly, ML; Herschlag, D; Al-Hashimi, HM
Published in: Nat Rev Mol Cell Biol
August 2019

RNAs fold into 3D structures that range from simple helical elements to complex tertiary structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory RNAs depend on how their 3D structure changes in response to a diverse array of cellular conditions. In this Review, we examine how the structural characterization of RNA as dynamic ensembles of conformations, which form with different probabilities and at different timescales, is improving our understanding of RNA function in cells. We discuss the mechanisms of gene regulation by microRNAs, riboswitches, ribozymes, post-transcriptional RNA modifications and RNA-binding proteins, and how the cellular environment and processes such as liquid-liquid phase separation may affect RNA folding and activity. The emerging RNA-ensemble-function paradigm is changing our perspective and understanding of RNA regulation, from in vitro to in vivo and from descriptive to predictive.

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Published In

Nat Rev Mol Cell Biol

DOI

EISSN

1471-0080

Publication Date

August 2019

Volume

20

Issue

8

Start / End Page

474 / 489

Location

England

Related Subject Headings

  • RNA-Binding Proteins
  • RNA, Catalytic
  • RNA Processing, Post-Transcriptional
  • RNA Folding
  • Humans
  • Gene Expression Regulation
  • Developmental Biology
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
 

Citation

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Ganser, L. R., Kelly, M. L., Herschlag, D., & Al-Hashimi, H. M. (2019). The roles of structural dynamics in the cellular functions of RNAs. Nat Rev Mol Cell Biol, 20(8), 474–489. https://doi.org/10.1038/s41580-019-0136-0
Ganser, Laura R., Megan L. Kelly, Daniel Herschlag, and Hashim M. Al-Hashimi. “The roles of structural dynamics in the cellular functions of RNAs.Nat Rev Mol Cell Biol 20, no. 8 (August 2019): 474–89. https://doi.org/10.1038/s41580-019-0136-0.
Ganser LR, Kelly ML, Herschlag D, Al-Hashimi HM. The roles of structural dynamics in the cellular functions of RNAs. Nat Rev Mol Cell Biol. 2019 Aug;20(8):474–89.
Ganser, Laura R., et al. “The roles of structural dynamics in the cellular functions of RNAs.Nat Rev Mol Cell Biol, vol. 20, no. 8, Aug. 2019, pp. 474–89. Pubmed, doi:10.1038/s41580-019-0136-0.
Ganser LR, Kelly ML, Herschlag D, Al-Hashimi HM. The roles of structural dynamics in the cellular functions of RNAs. Nat Rev Mol Cell Biol. 2019 Aug;20(8):474–489.

Published In

Nat Rev Mol Cell Biol

DOI

EISSN

1471-0080

Publication Date

August 2019

Volume

20

Issue

8

Start / End Page

474 / 489

Location

England

Related Subject Headings

  • RNA-Binding Proteins
  • RNA, Catalytic
  • RNA Processing, Post-Transcriptional
  • RNA Folding
  • Humans
  • Gene Expression Regulation
  • Developmental Biology
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences