Implementation, performance and characterization of the DiFrancesco-Noble model

The authors describe their experience in the implementation and the use of the DiFrancesco-Noble model. Clarifying references for the equations are given as well as a way to implement the equations in a propagation model. An estimate of the number of floating point operations required is given as well as the running times of functional programs in some widely used computers. A number of parameters useful in the design of numerical experiments like resting membrane resistance are also given. A short discussion on the accuracy of the equations for the fast sodium current is also included as well as some modifications made to the DiFrancesco-Noble equations, so that the depolarization rate was closer to real tissue experiments.

Duke Scholars

Author Roger C. Barr Biomedical Engineering