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Emerging Opportunities To Manipulate Metal Trafficking for Therapeutic Benefit.

Publication ,  Journal Article
Hunsaker, EW; Franz, KJ
Published in: Inorganic chemistry
October 2019

The indispensable requirement for metals in life processes has led to the evolution of sophisticated mechanisms that allow organisms to maintain dynamic equilibria of these ions. This dynamic control of the level, speciation, and availability of a variety of metal ions allows organisms to sustain biological processes while avoiding toxicity. When functioning properly, these mechanisms allow cells to return to their metal homeostatic set points following shifts in the metal availability or other stressors. These periods of transition, when cells are in a state of flux in which they work to regain homeostasis, present windows of opportunity to pharmacologically manipulate targets associated with metal-trafficking pathways in ways that could either facilitate a return to homeostasis and the recovery of cellular function or further push cells outside of homeostasis and into cellular distress. The purpose of this Viewpoint is to highlight emerging opportunities for chemists and chemical biologists to develop compounds to manipulate metal-trafficking processes for therapeutic benefit.

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Published In

Inorganic chemistry

DOI

EISSN

1520-510X

ISSN

0020-1669

Publication Date

October 2019

Volume

58

Issue

20

Start / End Page

13528 / 13545

Related Subject Headings

  • Organic Chemicals
  • Neoplasms
  • Metals
  • Metabolic Diseases
  • Inorganic & Nuclear Chemistry
  • Humans
  • Homeostasis
  • 3403 Macromolecular and materials chemistry
  • 3402 Inorganic chemistry
  • 0399 Other Chemical Sciences
 

Citation

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Hunsaker, E. W., & Franz, K. J. (2019). Emerging Opportunities To Manipulate Metal Trafficking for Therapeutic Benefit. Inorganic Chemistry, 58(20), 13528–13545. https://doi.org/10.1021/acs.inorgchem.9b01029
Hunsaker, Elizabeth W., and Katherine J. Franz. “Emerging Opportunities To Manipulate Metal Trafficking for Therapeutic Benefit.Inorganic Chemistry 58, no. 20 (October 2019): 13528–45. https://doi.org/10.1021/acs.inorgchem.9b01029.
Hunsaker EW, Franz KJ. Emerging Opportunities To Manipulate Metal Trafficking for Therapeutic Benefit. Inorganic chemistry. 2019 Oct;58(20):13528–45.
Hunsaker, Elizabeth W., and Katherine J. Franz. “Emerging Opportunities To Manipulate Metal Trafficking for Therapeutic Benefit.Inorganic Chemistry, vol. 58, no. 20, Oct. 2019, pp. 13528–45. Epmc, doi:10.1021/acs.inorgchem.9b01029.
Hunsaker EW, Franz KJ. Emerging Opportunities To Manipulate Metal Trafficking for Therapeutic Benefit. Inorganic chemistry. 2019 Oct;58(20):13528–13545.
Journal cover image

Published In

Inorganic chemistry

DOI

EISSN

1520-510X

ISSN

0020-1669

Publication Date

October 2019

Volume

58

Issue

20

Start / End Page

13528 / 13545

Related Subject Headings

  • Organic Chemicals
  • Neoplasms
  • Metals
  • Metabolic Diseases
  • Inorganic & Nuclear Chemistry
  • Humans
  • Homeostasis
  • 3403 Macromolecular and materials chemistry
  • 3402 Inorganic chemistry
  • 0399 Other Chemical Sciences