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Renal cell carcinoma suspected at time of organ donation 2008-2016: A report of the OPTN ad hoc Disease Transmission Advisory Committee Registry.

Publication ,  Journal Article
Pavlakis, M; Michaels, MG; Tlusty, S; Turgeon, N; Vece, G; Wolfe, C; Wood, RP; Nalesnik, MA
Published in: Clin Transplant
July 2019

All 179 reports to the OPTN of potential renal cell carcinoma (RCC) transmission from 1/1/2008 through 12/31/2016 were reviewed. Cases were divided into those with donor tumor known or suspected at time of transplant (N = 147 donors), and those in which tumor was initially found after transplant (N = 32). We sought to understand the risk of transplanting either the affected kidney, the contralateral kidney or non-renal organs from donors with a suspected/confirmed unilateral RCC. In the case of RCC found prior to transplant, transplantation of 21 kidneys following excision of tumor, 47 contralateral kidneys and 198 non-renal organs was performed. No cases of RCC transmission were documented in this population. An additional six cases of live donor kidney transplantation involving resection of RCC were reported, also without transmission. Six of 9 other recipients in whom the diagnosis of RCC became available after implantation underwent allograft nephrectomy and 3 received tumor resection. No recurrent RCC was documented. Given the low rate of transmission and available treatment options, consideration should be given to judicious use of organs from donors with small solitary RCC.

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Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

July 2019

Volume

33

Issue

7

Start / End Page

e13597

Location

Denmark

Related Subject Headings

  • Tissue and Organ Procurement
  • Tissue Donors
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Registries
  • Prognosis
  • Nephrectomy
  • Middle Aged
  • Male
 

Citation

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Pavlakis, M., Michaels, M. G., Tlusty, S., Turgeon, N., Vece, G., Wolfe, C., … Nalesnik, M. A. (2019). Renal cell carcinoma suspected at time of organ donation 2008-2016: A report of the OPTN ad hoc Disease Transmission Advisory Committee Registry. Clin Transplant, 33(7), e13597. https://doi.org/10.1111/ctr.13597
Pavlakis, Martha, Marian G. Michaels, Susan Tlusty, Nicole Turgeon, Gabriel Vece, Cameron Wolfe, R Patrick Wood, and Michael A. Nalesnik. “Renal cell carcinoma suspected at time of organ donation 2008-2016: A report of the OPTN ad hoc Disease Transmission Advisory Committee Registry.Clin Transplant 33, no. 7 (July 2019): e13597. https://doi.org/10.1111/ctr.13597.
Pavlakis M, Michaels MG, Tlusty S, Turgeon N, Vece G, Wolfe C, et al. Renal cell carcinoma suspected at time of organ donation 2008-2016: A report of the OPTN ad hoc Disease Transmission Advisory Committee Registry. Clin Transplant. 2019 Jul;33(7):e13597.
Pavlakis, Martha, et al. “Renal cell carcinoma suspected at time of organ donation 2008-2016: A report of the OPTN ad hoc Disease Transmission Advisory Committee Registry.Clin Transplant, vol. 33, no. 7, July 2019, p. e13597. Pubmed, doi:10.1111/ctr.13597.
Pavlakis M, Michaels MG, Tlusty S, Turgeon N, Vece G, Wolfe C, Wood RP, Nalesnik MA. Renal cell carcinoma suspected at time of organ donation 2008-2016: A report of the OPTN ad hoc Disease Transmission Advisory Committee Registry. Clin Transplant. 2019 Jul;33(7):e13597.
Journal cover image

Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

July 2019

Volume

33

Issue

7

Start / End Page

e13597

Location

Denmark

Related Subject Headings

  • Tissue and Organ Procurement
  • Tissue Donors
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Registries
  • Prognosis
  • Nephrectomy
  • Middle Aged
  • Male