Translational impact of NIH-funded nonhuman primate research in transplantation.
Publication
, Journal Article
Knechtle, SJ; Shaw, JM; Hering, BJ; Kraemer, K; Madsen, JC
Published in: Sci Transl Med
July 10, 2019
The National Institutes of Health (NIH) has long supported using nonhuman primate (NHP) models for research on kidney, pancreatic islet, heart, and lung transplantation. The primary purpose of this research has been to develop new treatments for down-modulating or preventing deleterious immune responses after transplantation in human patients. Here, we discuss NIH-funded NHP studies of immune cell depletion, costimulation blockade, regulatory cell therapy, desensitization, and mixed hematopoietic chimerism that either preceded clinical trials or prevented the human application of therapies that were toxic or ineffective.
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Published In
Sci Transl Med
DOI
EISSN
1946-6242
Publication Date
July 10, 2019
Volume
11
Issue
500
Location
United States
Related Subject Headings
- United States
- Transplantation
- Translational Research, Biomedical
- Primates
- National Institutes of Health (U.S.)
- Immunotherapy
- Immunologic Memory
- Humans
- Chimerism
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Knechtle, S. J., Shaw, J. M., Hering, B. J., Kraemer, K., & Madsen, J. C. (2019). Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med, 11(500). https://doi.org/10.1126/scitranslmed.aau0143
Knechtle, Stuart J., Julia M. Shaw, Bernhard J. Hering, Kristy Kraemer, and Joren C. Madsen. “Translational impact of NIH-funded nonhuman primate research in transplantation.” Sci Transl Med 11, no. 500 (July 10, 2019). https://doi.org/10.1126/scitranslmed.aau0143.
Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500).
Knechtle, Stuart J., et al. “Translational impact of NIH-funded nonhuman primate research in transplantation.” Sci Transl Med, vol. 11, no. 500, July 2019. Pubmed, doi:10.1126/scitranslmed.aau0143.
Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC. Translational impact of NIH-funded nonhuman primate research in transplantation. Sci Transl Med. 2019 Jul 10;11(500).
Published In
Sci Transl Med
DOI
EISSN
1946-6242
Publication Date
July 10, 2019
Volume
11
Issue
500
Location
United States
Related Subject Headings
- United States
- Transplantation
- Translational Research, Biomedical
- Primates
- National Institutes of Health (U.S.)
- Immunotherapy
- Immunologic Memory
- Humans
- Chimerism
- Animals