Skip to main content
Journal cover image

Influence of Inflammatory and Oxidative Stress Pathways on Longitudinal Symptom Experiences in Children With Leukemia.

Publication ,  Journal Article
Hockenberry, MJ; Pan, W; Scheurer, ME; Hooke, MC; Taylor, O; Koerner, K; Montgomery, D; Whitman, S; Mitby, P; Moore, I
Published in: Biological research for nursing
October 2019

The purpose of this study was to explore the influence of oxidative stress (F2-isoprostanes) and inflammatory (interleukin [IL]-8) biomarkers on symptom trajectories during the first 18 months of childhood leukemia treatment.A repeated-measures design was used to evaluate symptoms experienced by 218 children during treatment. A symptom cluster (fatigue, pain, and nausea) was explored over four time periods: initiation of post-induction therapy, 4 and 8 months into post-induction therapy, and the beginning of maintenance therapy (12 months postinduction). F2-isoprostanes and IL-8 were evaluated in cerebrospinal fluid (CSF) samples collected at baseline (diagnosis) and then at the four time periods. The longitudinal relationships of these biomarkers with the symptom cluster were examined using the longitudinal parallel process.Pain and fatigue levels were highest during the post-induction phases of treatment and decreased slightly during maintenance therapy, while nausea scores were relatively stable. Even in the later phases of treatment, children continued to experience symptoms. CSF levels of the biomarkers increased during the post-induction phases of treatment. Early increases in the biomarkers were associated with more severe symptoms during the same period; patients who had increased biomarkers over time also experienced more severe symptoms over time.Findings reveal that children experienced symptoms throughout the course of leukemia treatment and support hypothesized longitudinal relationships of oxidative stress and inflammatory biomarkers with symptom severity. Activation of the biomarker pathways during treatment may explain underlying mechanisms of symptom experiences and identify which children are at risk for severe symptoms.

Duke Scholars

Published In

Biological research for nursing

DOI

EISSN

1552-4175

ISSN

1099-8004

Publication Date

October 2019

Volume

21

Issue

5

Start / End Page

458 / 465

Related Subject Headings

  • Syndrome
  • Pain
  • Oxidative Stress
  • Nursing
  • Nausea
  • Male
  • Longitudinal Studies
  • Leukemia
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hockenberry, M. J., Pan, W., Scheurer, M. E., Hooke, M. C., Taylor, O., Koerner, K., … Moore, I. (2019). Influence of Inflammatory and Oxidative Stress Pathways on Longitudinal Symptom Experiences in Children With Leukemia. Biological Research for Nursing, 21(5), 458–465. https://doi.org/10.1177/1099800419863160
Hockenberry, Marilyn J., Wei Pan, Michael E. Scheurer, Mary C. Hooke, Olga Taylor, Kari Koerner, David Montgomery, Susan Whitman, Pauline Mitby, and Ida Moore. “Influence of Inflammatory and Oxidative Stress Pathways on Longitudinal Symptom Experiences in Children With Leukemia.Biological Research for Nursing 21, no. 5 (October 2019): 458–65. https://doi.org/10.1177/1099800419863160.
Hockenberry MJ, Pan W, Scheurer ME, Hooke MC, Taylor O, Koerner K, et al. Influence of Inflammatory and Oxidative Stress Pathways on Longitudinal Symptom Experiences in Children With Leukemia. Biological research for nursing. 2019 Oct;21(5):458–65.
Hockenberry, Marilyn J., et al. “Influence of Inflammatory and Oxidative Stress Pathways on Longitudinal Symptom Experiences in Children With Leukemia.Biological Research for Nursing, vol. 21, no. 5, Oct. 2019, pp. 458–65. Epmc, doi:10.1177/1099800419863160.
Hockenberry MJ, Pan W, Scheurer ME, Hooke MC, Taylor O, Koerner K, Montgomery D, Whitman S, Mitby P, Moore I. Influence of Inflammatory and Oxidative Stress Pathways on Longitudinal Symptom Experiences in Children With Leukemia. Biological research for nursing. 2019 Oct;21(5):458–465.
Journal cover image

Published In

Biological research for nursing

DOI

EISSN

1552-4175

ISSN

1099-8004

Publication Date

October 2019

Volume

21

Issue

5

Start / End Page

458 / 465

Related Subject Headings

  • Syndrome
  • Pain
  • Oxidative Stress
  • Nursing
  • Nausea
  • Male
  • Longitudinal Studies
  • Leukemia
  • Humans
  • Female