Skip to main content

CORRELATION OF SUBRETINAL HYPERREFLECTIVE MATERIAL MORPHOLOGY AND VISUAL ACUITY IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.

Publication ,  Journal Article
Kumar, JB; Stinnett, S; Han, JIL; Jaffe, GJ
Published in: Retina
May 2020

PURPOSE: To evaluate the association of subretinal hyperreflective material (SHRM) morphological features with visual acuity in eyes with neovascular age-related macular degeneration. METHODS: Retrospective analysis of treatment-naïve patients with neovascular age-related macular degeneration enrolled in randomized anti-vascular endothelial growth factor (VEGF) and anti-platelet-derived growth factor clinical trials. Standardized spectral domain optical coherence tomography images were graded at baseline, 12-week, and 24-week follow-up visits. Masked readers evaluated the morphology of SHRM (reflectivity, shape, anterior, and posterior boundaries) and measured SHRM height, width, and area at the fovea, within the center 1 mm, and outside the center 1 mm. RESULTS: Baseline SHRM characteristics that correlated with worse visual acuity at 12 and 24 weeks included layered appearance (P = 0.006, 0.001), hyperreflective spots in SHRM (P = 0.001, 0.011), and separation between SHRM and outer retina (P = 0.03, 0.019). The disappearance of SHRM correlated with better visual acuity at Weeks 12 and 24 (P < 0.001). Layered appearance of SHRM at baseline was significantly associated with increased reflectivity at Weeks 12 and 24 (P = 0.009, 0.003). Decreasing reflectivity of SHRM lesion at Weeks 12 and 24 correlated with better visual acuity (P < 0.01, 0.01). Increased width and area of baseline SHRM at the foveal center correlated with worse visual acuity at 12 (P < 0.001, <0.001) and 24 weeks (<0.001, <0.001). CONCLUSION: Several attributes of SHRM including, layered appearance, increased reflectivity, larger size, and hyperreflective spots correlated with worse visual acuity at 12- and 24-week follow-ups. Baseline SHRM characteristics can help practitioners predict visual and morphological prognosis and guide therapy.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Retina

DOI

EISSN

1539-2864

Publication Date

May 2020

Volume

40

Issue

5

Start / End Page

845 / 856

Location

United States

Related Subject Headings

  • Wet Macular Degeneration
  • Visual Acuity
  • Vascular Endothelial Growth Factor A
  • Tomography, Optical Coherence
  • Thymidine Phosphorylase
  • Retrospective Studies
  • Ranibizumab
  • Prognosis
  • Ophthalmology & Optometry
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kumar, J. B., Stinnett, S., Han, J. I. L., & Jaffe, G. J. (2020). CORRELATION OF SUBRETINAL HYPERREFLECTIVE MATERIAL MORPHOLOGY AND VISUAL ACUITY IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. Retina, 40(5), 845–856. https://doi.org/10.1097/IAE.0000000000002552
Kumar, Jaya B., Sandra Stinnett, Jung I. L. Han, and Glenn J. Jaffe. “CORRELATION OF SUBRETINAL HYPERREFLECTIVE MATERIAL MORPHOLOGY AND VISUAL ACUITY IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.Retina 40, no. 5 (May 2020): 845–56. https://doi.org/10.1097/IAE.0000000000002552.
Kumar, Jaya B., et al. “CORRELATION OF SUBRETINAL HYPERREFLECTIVE MATERIAL MORPHOLOGY AND VISUAL ACUITY IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.Retina, vol. 40, no. 5, May 2020, pp. 845–56. Pubmed, doi:10.1097/IAE.0000000000002552.

Published In

Retina

DOI

EISSN

1539-2864

Publication Date

May 2020

Volume

40

Issue

5

Start / End Page

845 / 856

Location

United States

Related Subject Headings

  • Wet Macular Degeneration
  • Visual Acuity
  • Vascular Endothelial Growth Factor A
  • Tomography, Optical Coherence
  • Thymidine Phosphorylase
  • Retrospective Studies
  • Ranibizumab
  • Prognosis
  • Ophthalmology & Optometry
  • Middle Aged