Outcomes of Treatment of Gestational Trophoblastic Neoplasia in a Primarily Indigent Urban Population.
OBJECTIVE: To review outcomes of women with gestational trophoblastic neoplasia (GTN) who presented to an inner-city hospital system, given that the rigorous treatment and follow-up for GTN is often problematic for certain women of low socioeconomic status with limited resources and social support. STUDY DESIGN: A retrospective review was performed with IRB approval of patients diagnosed with GTN based on the revised WHO scoring system from 1999-2010 at our institution. SPSS Statistics software was used to perform univariate and multivariate analyses. RESULTS: Forty-nine patients were treated for GTN: 32 low-risk and 17 high-risk. Low-risk patients received an average of 5 cycles of initial single-agent chemotherapy. Six patients had persistent disease and were switched to a second single-agent regimen. One patient required multiagent chemotherapy for normalization of human chorionic gonadotropin levels. No patient had recurrence of disease. All high-risk patients were initially treated with multiagent chemotherapy, averaging 8 cycles. Two of the 17 patients persisted; 1 recurred. All 3 currently have no evidence of disease. No patient died of disease. CONCLUSION: Excellent treatment outcomes in patients with GTN may be achieved in disadvantaged populations when compliance to regimens is optimized.
Duke Scholars
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- Young Adult
- Urban Population
- Texas
- Retrospective Studies
- Pregnancy
- Poverty
- Obstetrics & Reproductive Medicine
- Hysterectomy
- Humans
- Gestational Trophoblastic Disease
Citation
Published In
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Young Adult
- Urban Population
- Texas
- Retrospective Studies
- Pregnancy
- Poverty
- Obstetrics & Reproductive Medicine
- Hysterectomy
- Humans
- Gestational Trophoblastic Disease