Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria.
Publication
, Journal Article
Nunnery, JK; Engene, N; Byrum, T; Cao, Z; Jabba, SV; Pereira, AR; Matainaho, T; Murray, TF; Gerwick, WH
Published in: The Journal of organic chemistry
May 2012
Five new vinylchlorine-containing metabolites, the lipoamides janthielamide A and kimbeamides A-C and the ketide-extended pyranone kimbelactone A, have been isolated from collections of marine cyanobacteria made in Curaçao and Papua New Guinea. Both janthielamide A and kimbeamide A exhibited moderate sodium channel blocking activity in murine Neuro-2a cells. Consistent with this activity, janthielamide A was also found to antagonize veratridine-induced sodium influx in murine cerebrocortical neurons. These lipoamides represent the newest additions to a relatively rare family of marine cyanobacterial-derived lipoamides and a new structural class of compounds exhibiting neuromodulatory activities from marine cyanobacteria.
Duke Scholars
Published In
The Journal of organic chemistry
DOI
EISSN
1520-6904
ISSN
0022-3263
Publication Date
May 2012
Volume
77
Issue
9
Start / End Page
4198 / 4208
Related Subject Headings
- Vinyl Compounds
- Thioctic Acid
- Organic Chemistry
- Nuclear Magnetic Resonance, Biomolecular
- Neurotransmitter Agents
- Molecular Structure
- Mice
- Halogenation
- Geography
- Cyanobacteria
Citation
APA
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ICMJE
MLA
NLM
Nunnery, J. K., Engene, N., Byrum, T., Cao, Z., Jabba, S. V., Pereira, A. R., … Gerwick, W. H. (2012). Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria. The Journal of Organic Chemistry, 77(9), 4198–4208. https://doi.org/10.1021/jo300160e
Nunnery, Joshawna K., Niclas Engene, Tara Byrum, Zhengyu Cao, Sairam V. Jabba, Alban R. Pereira, Teatulohi Matainaho, Thomas F. Murray, and William H. Gerwick. “Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria.” The Journal of Organic Chemistry 77, no. 9 (May 2012): 4198–4208. https://doi.org/10.1021/jo300160e.
Nunnery JK, Engene N, Byrum T, Cao Z, Jabba SV, Pereira AR, et al. Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria. The Journal of organic chemistry. 2012 May;77(9):4198–208.
Nunnery, Joshawna K., et al. “Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria.” The Journal of Organic Chemistry, vol. 77, no. 9, May 2012, pp. 4198–208. Epmc, doi:10.1021/jo300160e.
Nunnery JK, Engene N, Byrum T, Cao Z, Jabba SV, Pereira AR, Matainaho T, Murray TF, Gerwick WH. Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria. The Journal of organic chemistry. 2012 May;77(9):4198–4208.
Published In
The Journal of organic chemistry
DOI
EISSN
1520-6904
ISSN
0022-3263
Publication Date
May 2012
Volume
77
Issue
9
Start / End Page
4198 / 4208
Related Subject Headings
- Vinyl Compounds
- Thioctic Acid
- Organic Chemistry
- Nuclear Magnetic Resonance, Biomolecular
- Neurotransmitter Agents
- Molecular Structure
- Mice
- Halogenation
- Geography
- Cyanobacteria