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Ductal Carcinoma In Situ Management: All or Nothing, or Something in between?

Publication ,  Journal Article
Plichta, JK; Rosenberger, LH; DeChant, CA; Hwang, ES
Published in: Current Breast Cancer Reports
September 15, 2019

Purpose of Review: Standard treatment for ductal carcinoma in situ (DCIS) is similar to that of invasive carcinoma. However, there is significant controversy regarding the true clinical implications of DCIS, and thus, the best management strategy. The aim of this review is to highlight relevant biology, diagnostic considerations, treatment options, and recent clinical trials. Recent Findings: Outcomes are generally excellent with low recurrence rates and exceptional disease-specific survival. Outcomes can be predicted using various prognostic indicators and/or nomograms to guide treatment decisions. Ongoing clinical trials of active surveillance are based upon the argument that ipsilateral invasive recurrence is the most clinically meaningful endpoint. These trials seek to compare ipsilateral invasive cancer diagnoses between standard of care and close monitoring. Summary: Recent trials have revealed the marked heterogeneity in the biology of DCIS, offering an opportunity to de-escalate therapy for women at lowest risk for progression. DCIS also presents an ideal setting in which to test novel prevention agents. Future care of patients with DCIS will include biomarker-based risk assessment in order to better individualize treatment to biologic risk of invasive progression.

Duke Scholars

Published In

Current Breast Cancer Reports

DOI

EISSN

1943-4596

ISSN

1943-4588

Publication Date

September 15, 2019

Volume

11

Issue

3

Start / End Page

190 / 202

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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MLA
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Plichta, J. K., Rosenberger, L. H., DeChant, C. A., & Hwang, E. S. (2019). Ductal Carcinoma In Situ Management: All or Nothing, or Something in between? Current Breast Cancer Reports, 11(3), 190–202. https://doi.org/10.1007/s12609-019-0306-2
Plichta, J. K., L. H. Rosenberger, C. A. DeChant, and E. S. Hwang. “Ductal Carcinoma In Situ Management: All or Nothing, or Something in between?Current Breast Cancer Reports 11, no. 3 (September 15, 2019): 190–202. https://doi.org/10.1007/s12609-019-0306-2.
Plichta JK, Rosenberger LH, DeChant CA, Hwang ES. Ductal Carcinoma In Situ Management: All or Nothing, or Something in between? Current Breast Cancer Reports. 2019 Sep 15;11(3):190–202.
Plichta, J. K., et al. “Ductal Carcinoma In Situ Management: All or Nothing, or Something in between?Current Breast Cancer Reports, vol. 11, no. 3, Sept. 2019, pp. 190–202. Scopus, doi:10.1007/s12609-019-0306-2.
Plichta JK, Rosenberger LH, DeChant CA, Hwang ES. Ductal Carcinoma In Situ Management: All or Nothing, or Something in between? Current Breast Cancer Reports. 2019 Sep 15;11(3):190–202.
Journal cover image

Published In

Current Breast Cancer Reports

DOI

EISSN

1943-4596

ISSN

1943-4588

Publication Date

September 15, 2019

Volume

11

Issue

3

Start / End Page

190 / 202

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis