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On-chip collection of particles and cells by AC electroosmotic pumping and dielectrophoresis using asymmetric microelectrodes

Publication ,  Journal Article
Melvin, EM; Moore, BR; Gilchrist, KH; Grego, S; Velev, OD
Published in: Biomicrofluidics
January 1, 2011

The recent development of microfluidic "lab on a chip" devices requiring sample sizes <100 μL has given rise to the need to concentrate dilute samples and trap analytes, especially for surface-based detection techniques. We demonstrate a particle collection device capable of concentrating micron-sized particles in a predetermined area by combining AC electroosmosis (ACEO) and dielectrophoresis (DEP). The planar asymmetric electrode pattern uses ACEO pumping to induce equal, quadrilateral flow directed towards a stagnant region in the center of the device. A number of system parameters affecting particle collection efficiency were investigated including electrode and gap width, chamber height, applied potential and frequency, and number of repeating electrode pairs and electrode geometry. The robustness of the on-chip collection design was evaluated against varying electrolyte concentrations, particle types, and particle sizes. These devices are amenable to integration with a variety of detection techniques such as optical evanescent waveguide sensing. © 2011 American Institute of Physics.

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Published In

Biomicrofluidics

DOI

ISSN

1932-1058

Publication Date

January 1, 2011

Volume

5

Issue

3

Related Subject Headings

  • Nanoscience & Nanotechnology
  • 4012 Fluid mechanics and thermal engineering
  • 1007 Nanotechnology
  • 0915 Interdisciplinary Engineering
  • 0203 Classical Physics
 

Citation

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Melvin, E. M., Moore, B. R., Gilchrist, K. H., Grego, S., & Velev, O. D. (2011). On-chip collection of particles and cells by AC electroosmotic pumping and dielectrophoresis using asymmetric microelectrodes. Biomicrofluidics, 5(3). https://doi.org/10.1063/1.3620419
Melvin, E. M., B. R. Moore, K. H. Gilchrist, S. Grego, and O. D. Velev. “On-chip collection of particles and cells by AC electroosmotic pumping and dielectrophoresis using asymmetric microelectrodes.” Biomicrofluidics 5, no. 3 (January 1, 2011). https://doi.org/10.1063/1.3620419.
Melvin EM, Moore BR, Gilchrist KH, Grego S, Velev OD. On-chip collection of particles and cells by AC electroosmotic pumping and dielectrophoresis using asymmetric microelectrodes. Biomicrofluidics. 2011 Jan 1;5(3).
Melvin, E. M., et al. “On-chip collection of particles and cells by AC electroosmotic pumping and dielectrophoresis using asymmetric microelectrodes.” Biomicrofluidics, vol. 5, no. 3, Jan. 2011. Scopus, doi:10.1063/1.3620419.
Melvin EM, Moore BR, Gilchrist KH, Grego S, Velev OD. On-chip collection of particles and cells by AC electroosmotic pumping and dielectrophoresis using asymmetric microelectrodes. Biomicrofluidics. 2011 Jan 1;5(3).

Published In

Biomicrofluidics

DOI

ISSN

1932-1058

Publication Date

January 1, 2011

Volume

5

Issue

3

Related Subject Headings

  • Nanoscience & Nanotechnology
  • 4012 Fluid mechanics and thermal engineering
  • 1007 Nanotechnology
  • 0915 Interdisciplinary Engineering
  • 0203 Classical Physics