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Effects of cancer history on functional age and mortality.

Publication ,  Journal Article
Blair, CK; Jacobs, DR; Demark-Wahnefried, W; Cohen, HJ; Morey, MC; Robien, K; Lazovich, D
Published in: Cancer
December 1, 2019

BACKGROUND: Cancer, its treatment, and associated adverse effects may accelerate the functional aging of cancer survivors. In the current study, the authors used geriatric assessment (GA) to compare the functional age of long-term cancer survivors with that of similarly aged women without a cancer history, and to examine whether functional age influences all-cause mortality differently between these 2 groups. METHODS: Participants included 1723 cancer survivors and 11,145 age-matched, cancer-free women enrolled in the Iowa Women's Health Study in 1986 who completed the 2004 questionnaire (at ages 73-88 years). GA domain deficits included ≥2 physical function limitations, ≥2 comorbidities, poor general health, poor mental health, and underweight. The risk of all-cause mortality was estimated for deficits in each GA domain between 4 groups based on the cross-classification of the presence and/or absence of cancer history and GA domain deficit (the referent group was cancer-free women without a GA deficit). RESULTS: Both cancer history and GA domain deficits significantly predicted 10-year mortality for all GA domains. Cancer survivors without deficits had a 1.3-fold to 1.4-fold risk of mortality, similar to the 1.1-fold to 1.7-fold risk noted among cancer-free women with deficits (all P < .05). Cancer survivors with deficits were found to have the highest mortality risk for 4 of 5 domains (hazard ratio range, 1.6-2.0). Mortality risk increased with the increasing number of GA deficits, which was greater in cancer survivors compared with cancer-free women. CONCLUSIONS: Even without GA deficits, cancer survivors appear to have an excess risk of death compared with women without cancer, and these deficits add to mortality risk. Interventions are needed to maintain or improve functional/physiological capacity as women age, especially in cancer survivors.

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Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

December 1, 2019

Volume

125

Issue

23

Start / End Page

4303 / 4309

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasms
  • Male
  • Humans
  • Female
  • Cancer Survivors
  • Aged, 80 and over
  • Aged
  • Age Factors
  • 4206 Public health
 

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Blair, C. K., Jacobs, D. R., Demark-Wahnefried, W., Cohen, H. J., Morey, M. C., Robien, K., & Lazovich, D. (2019). Effects of cancer history on functional age and mortality. Cancer, 125(23), 4303–4309. https://doi.org/10.1002/cncr.32449
Blair, Cindy K., David R. Jacobs, Wendy Demark-Wahnefried, Harvey J. Cohen, Miriam C. Morey, Kim Robien, and DeAnn Lazovich. “Effects of cancer history on functional age and mortality.Cancer 125, no. 23 (December 1, 2019): 4303–9. https://doi.org/10.1002/cncr.32449.
Blair CK, Jacobs DR, Demark-Wahnefried W, Cohen HJ, Morey MC, Robien K, et al. Effects of cancer history on functional age and mortality. Cancer. 2019 Dec 1;125(23):4303–9.
Blair, Cindy K., et al. “Effects of cancer history on functional age and mortality.Cancer, vol. 125, no. 23, Dec. 2019, pp. 4303–09. Pubmed, doi:10.1002/cncr.32449.
Blair CK, Jacobs DR, Demark-Wahnefried W, Cohen HJ, Morey MC, Robien K, Lazovich D. Effects of cancer history on functional age and mortality. Cancer. 2019 Dec 1;125(23):4303–4309.
Journal cover image

Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

December 1, 2019

Volume

125

Issue

23

Start / End Page

4303 / 4309

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasms
  • Male
  • Humans
  • Female
  • Cancer Survivors
  • Aged, 80 and over
  • Aged
  • Age Factors
  • 4206 Public health