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A cultural adaptation and validation study of a self-report measure of the extent of and reasons for medication nonadherence among patients with diabetes in Singapore.

Publication ,  Journal Article
Liau, YW; Cheow, C; Leung, KTY; Tan, H; Low, SF; Cheen, HHM; Lim, WC; Tan, LL; Tan, JZY; Lee, ES; Xu, SJ; Tan, CYK; Phang, JW; Phang, JK ...
Published in: Patient Prefer Adherence
2019

BACKGROUND: This self-report measure is a new instrument to measure the extent of and reasons for medication adherence separately. However, few studies have assessed its psychometric properties in diabetic patients and also in Asian populations. OBJECTIVES: To validate this self-report measure in diabetic patients in Singapore. METHODS: We collected data prospectively using a questionnaire among 393 diabetic patients from hospitals in Singapore from July 2018 to January 2019. Using the COnsensus-based Standards for the selection of health Measurement INstruments framework, we assessed face validity, internal consistency, test-retest reliability, structural validity, and measurement error. We tested four a priori hypotheses on correlation of extent score with patient-reported outcome measures to assess construct validity. We examined cross-cultural validity via measurement invariance across gender, age groups, and languages. RESULTS: We performed cognitive interviews with 30 consenting English-literate, Chinese-literate, and Malay-literate (10 patients per language) diabetic patients (age range 48-76 years, 53% male, disease duration range 1-30 years) and face validity was supported. Among 393 patients (mean age: 59.4±12.2 years, 50.9% female, 52.4% Chinese), we showed moderate internal consistency (Cronbach's alpha =0.67) and test-retest reliability (intra-class coefficient=0.56 [95% CI 0.37-0.70]). We calculated smallest detectable change as 0.80. We established construct validity by meeting all four hypotheses. We showed structural validity as confirmatory factor analysis confirmed a one-factor model, with excellent fit statistics (Comparative Fit Index=1.0; Tucker-Lewis Index=1.0; Root Mean Square Error of Approximation<0.001; Standardized Root Mean Residuals<0.001). Analysis of cross-cultural validity supported configural invariance model but not metric invariance and scalar invariance model. Caution must be taken against directly comparing extent scores across gender, age groups, and languages. CONCLUSION: This self-report measure is valid and reliable in measuring medication adherence in diabetic patients in Singapore.

Duke Scholars

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Published In

Patient Prefer Adherence

DOI

ISSN

1177-889X

Publication Date

2019

Volume

13

Start / End Page

1241 / 1252

Location

New Zealand

Related Subject Headings

  • 4203 Health services and systems
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liau, Y. W., Cheow, C., Leung, K. T. Y., Tan, H., Low, S. F., Cheen, H. H. M., … Kwan, Y. H. (2019). A cultural adaptation and validation study of a self-report measure of the extent of and reasons for medication nonadherence among patients with diabetes in Singapore. Patient Prefer Adherence, 13, 1241–1252. https://doi.org/10.2147/PPA.S208736
Liau, Yuan Wei, Celine Cheow, Kenneth Tin Yau Leung, Hejing Tan, Suat Fern Low, Hua Heng McVin Cheen, Woan Chyi Lim, et al. “A cultural adaptation and validation study of a self-report measure of the extent of and reasons for medication nonadherence among patients with diabetes in Singapore.Patient Prefer Adherence 13 (2019): 1241–52. https://doi.org/10.2147/PPA.S208736.
Liau, Yuan Wei, et al. “A cultural adaptation and validation study of a self-report measure of the extent of and reasons for medication nonadherence among patients with diabetes in Singapore.Patient Prefer Adherence, vol. 13, 2019, pp. 1241–52. Pubmed, doi:10.2147/PPA.S208736.
Liau YW, Cheow C, Leung KTY, Tan H, Low SF, Cheen HHM, Lim WC, Tan LL, Tan JZY, Lee ES, Xu SJ, Tan CYK, Phang JW, Phang JK, Lam MH, Blalock DV, Voils CI, Yap KZ, Kwan YH. A cultural adaptation and validation study of a self-report measure of the extent of and reasons for medication nonadherence among patients with diabetes in Singapore. Patient Prefer Adherence. 2019;13:1241–1252.

Published In

Patient Prefer Adherence

DOI

ISSN

1177-889X

Publication Date

2019

Volume

13

Start / End Page

1241 / 1252

Location

New Zealand

Related Subject Headings

  • 4203 Health services and systems
  • 1103 Clinical Sciences