Hepatitis C virus positive diffuse large B-cell lymphomas have distinct molecular features and lack BCL2 translocations.
BACKGROUND: The clinical presentation of patients with hepatitis C virus (HCV)-positive diffuse large B-cell lymphoma (DLBCL) is different from their HCV-negative counterparts, but the underlying molecular and pathological characteristics are largely under investigated. The virus has a role in lymphomagenesis, as witnessed by the curative potential of antiviral therapy in HCV-related low-grade B-cell lymphomas. METHODS: We performed a case-control study including 44 HCV-positive cases of de novo DLBCL, comparing them with 132 HCV-negative patients as controls (ratio 3 to 1). Cases and controls were matched for age, lactate dehydrogenase level and international prognostic index at presentation. Patients were studied by gene expression profiling for cell-of-origin determination and to perform differential expression analysis between groups, fluorescence in-situ hybridisation and immunohistochemistry for MYC, BCL2 and BCL6, TP53 mutations, and diagnostic specimens reviewed to exclude transformation from low-grade lymphoma. RESULTS: Compared to the HCV-negative controls, patients with HCV-positive de novo DLBCL had differential expression of genes that regulate innate immune response and modulate apoptotic pathways, have higher proliferative index, and lack BCL2 translocations. CONCLUSIONS: HCV-positive DLBCL have distinct molecular and pathological features compared to the HCV-negative counterparts.
Duke Scholars
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Related Subject Headings
- Translocation, Genetic
- Proto-Oncogene Proteins c-bcl-6
- Proto-Oncogene Proteins c-bcl-2
- Oncology & Carcinogenesis
- Middle Aged
- Male
- Lymphoma, Large B-Cell, Diffuse
- Humans
- Hepacivirus
- Genes, myc
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Translocation, Genetic
- Proto-Oncogene Proteins c-bcl-6
- Proto-Oncogene Proteins c-bcl-2
- Oncology & Carcinogenesis
- Middle Aged
- Male
- Lymphoma, Large B-Cell, Diffuse
- Humans
- Hepacivirus
- Genes, myc