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Life course socioeconomic status and DNA methylation in genes related to stress reactivity and inflammation: The multi-ethnic study of atherosclerosis.

Publication ,  Journal Article
Needham, BL; Smith, JA; Zhao, W; Wang, X; Mukherjee, B; Kardia, SLR; Shively, CA; Seeman, TE; Liu, Y; Diez Roux, AV
Published in: Epigenetics
2015

Epigenetic changes, such as DNA methylation, have been hypothesized to provide a link between the social environment and disease development. The purpose of this study was to examine associations between life course measures of socioeconomic status (SES) and DNA methylation (DNAm) in 18 genes related to stress reactivity and inflammation using a multi-level modeling approach that treats DNAm measurements as repeat measures within an individual. DNAm and gene expression were assessed in purified monocytes for a random subsample of 1,264 non-Hispanic white, African-American, and Hispanic participants aged 55-94 from the Multi-Ethnic Study of Atherosclerosis (MESA). After correction for multiple testing, we found that low childhood SES was associated with DNAm in 3 stress-related genes (AVP, FKBP5, OXTR) and 2 inflammation-related genes (CCL1, CD1D), low adult SES was associated with DNAm in one stress-related gene (AVP) and 5 inflammation-related genes (CD1D, F8, KLRG1, NLRP12, TLR3), and social mobility was associated with DNAm in 3 stress-related genes (AVP, FKBP5, OXTR) and 7 inflammation-related genes (CCL1, CD1D, F8, KLRG1, NLRP12, PYDC1, TLR3). In general, low SES was associated with increased DNAm. Expression data was available for 7 genes that showed a significant relationship between SES and DNAm. In 5 of these 7 genes (CD1D, F8, FKBP5, KLRG1, NLRP12), DNAm was associated with gene expression for at least one transcript, providing evidence of the potential functional consequences of alterations in DNAm related to SES. The results of this study reflect the biological complexity of epigenetic data and underscore the need for multi-disciplinary approaches to study how DNAm may contribute to the social patterning of disease.

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Published In

Epigenetics

DOI

EISSN

1559-2308

Publication Date

2015

Volume

10

Issue

10

Start / End Page

958 / 969

Location

United States

Related Subject Headings

  • White People
  • Stress, Psychological
  • Social Class
  • Protein Biosynthesis
  • Middle Aged
  • Male
  • Inflammation
  • Humans
  • Hispanic or Latino
  • Gene Expression Regulation
 

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Needham, B. L., Smith, J. A., Zhao, W., Wang, X., Mukherjee, B., Kardia, S. L. R., … Diez Roux, A. V. (2015). Life course socioeconomic status and DNA methylation in genes related to stress reactivity and inflammation: The multi-ethnic study of atherosclerosis. Epigenetics, 10(10), 958–969. https://doi.org/10.1080/15592294.2015.1085139
Needham, Belinda L., Jennifer A. Smith, Wei Zhao, Xu Wang, Bhramar Mukherjee, Sharon L. R. Kardia, Carol A. Shively, Teresa E. Seeman, Yongmei Liu, and Ava V. Diez Roux. “Life course socioeconomic status and DNA methylation in genes related to stress reactivity and inflammation: The multi-ethnic study of atherosclerosis.Epigenetics 10, no. 10 (2015): 958–69. https://doi.org/10.1080/15592294.2015.1085139.
Needham BL, Smith JA, Zhao W, Wang X, Mukherjee B, Kardia SLR, et al. Life course socioeconomic status and DNA methylation in genes related to stress reactivity and inflammation: The multi-ethnic study of atherosclerosis. Epigenetics. 2015;10(10):958–69.
Needham, Belinda L., et al. “Life course socioeconomic status and DNA methylation in genes related to stress reactivity and inflammation: The multi-ethnic study of atherosclerosis.Epigenetics, vol. 10, no. 10, 2015, pp. 958–69. Pubmed, doi:10.1080/15592294.2015.1085139.
Needham BL, Smith JA, Zhao W, Wang X, Mukherjee B, Kardia SLR, Shively CA, Seeman TE, Liu Y, Diez Roux AV. Life course socioeconomic status and DNA methylation in genes related to stress reactivity and inflammation: The multi-ethnic study of atherosclerosis. Epigenetics. 2015;10(10):958–969.

Published In

Epigenetics

DOI

EISSN

1559-2308

Publication Date

2015

Volume

10

Issue

10

Start / End Page

958 / 969

Location

United States

Related Subject Headings

  • White People
  • Stress, Psychological
  • Social Class
  • Protein Biosynthesis
  • Middle Aged
  • Male
  • Inflammation
  • Humans
  • Hispanic or Latino
  • Gene Expression Regulation