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Mitochondrial DNA Sequence Variation Associated With Peripheral Nerve Function in the Elderly.

Publication ,  Journal Article
Katzman, SM; Strotmeyer, ES; Nalls, MA; Zhao, Y; Mooney, S; Schork, N; Newman, AB; Harris, TB; Yaffe, K; Cummings, SR; Liu, Y; Tranah, GJ ...
Published in: J Gerontol A Biol Sci Med Sci
November 2015

BACKGROUND: Mitochondrial dysfunction is a prominent hallmark of many sensory neuropathies. The purpose of this study was to assess the influence of mitochondrial DNA sequence variation on peripheral nerve function in the population-based Health, Aging, and Body Composition Study. METHODS: We investigated the role of common mitochondrial DNA variation (n = 1,580) and complete mitochondrial DNA sequences (n = 138) on peroneal motor nerve conduction velocity and amplitude, average vibration detection threshold, and monofilament sensitivity. RESULTS: Nominal associations among common mitochondrial DNA variants and haplogroups were identified but were not statistically significant after adjustment for multiple comparisons. Sequence-based approaches were used to identify aggregate variant associations across the 16S rRNA (weighted-sum, p = 2E-05 and variable threshold, p = 9E-06) for nerve conduction velocity. Several of these rare 16S variants occurred at or near sites with earlier disease associations and are also in close proximity to the peptidyl transferase center, which is the catalytic center of the 16S rRNA CONCLUSIONS: These results suggest that sequence variation related to mitochondrial protein synthesis/assembly is associated with peripheral nerve function and may provide insight into targets for intervention or new clinical strategies to preserve nerve function in late life.

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Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

November 2015

Volume

70

Issue

11

Start / End Page

1400 / 1408

Location

United States

Related Subject Headings

  • Reaction Time
  • RNA, Ribosomal, 16S
  • Peroneal Nerve
  • Neural Conduction
  • Mutation
  • Male
  • Humans
  • Gerontology
  • Genotype
  • Female
 

Citation

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Katzman, S. M., Strotmeyer, E. S., Nalls, M. A., Zhao, Y., Mooney, S., Schork, N., … Health, Aging, and Body Composition Study, . (2015). Mitochondrial DNA Sequence Variation Associated With Peripheral Nerve Function in the Elderly. J Gerontol A Biol Sci Med Sci, 70(11), 1400–1408. https://doi.org/10.1093/gerona/glu175
Katzman, Shana M., Elsa S. Strotmeyer, Michael A. Nalls, Yiqiang Zhao, Sean Mooney, Nik Schork, Anne B. Newman, et al. “Mitochondrial DNA Sequence Variation Associated With Peripheral Nerve Function in the Elderly.J Gerontol A Biol Sci Med Sci 70, no. 11 (November 2015): 1400–1408. https://doi.org/10.1093/gerona/glu175.
Katzman SM, Strotmeyer ES, Nalls MA, Zhao Y, Mooney S, Schork N, et al. Mitochondrial DNA Sequence Variation Associated With Peripheral Nerve Function in the Elderly. J Gerontol A Biol Sci Med Sci. 2015 Nov;70(11):1400–8.
Katzman, Shana M., et al. “Mitochondrial DNA Sequence Variation Associated With Peripheral Nerve Function in the Elderly.J Gerontol A Biol Sci Med Sci, vol. 70, no. 11, Nov. 2015, pp. 1400–08. Pubmed, doi:10.1093/gerona/glu175.
Katzman SM, Strotmeyer ES, Nalls MA, Zhao Y, Mooney S, Schork N, Newman AB, Harris TB, Yaffe K, Cummings SR, Liu Y, Tranah GJ, Health, Aging, and Body Composition Study. Mitochondrial DNA Sequence Variation Associated With Peripheral Nerve Function in the Elderly. J Gerontol A Biol Sci Med Sci. 2015 Nov;70(11):1400–1408.
Journal cover image

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

November 2015

Volume

70

Issue

11

Start / End Page

1400 / 1408

Location

United States

Related Subject Headings

  • Reaction Time
  • RNA, Ribosomal, 16S
  • Peroneal Nerve
  • Neural Conduction
  • Mutation
  • Male
  • Humans
  • Gerontology
  • Genotype
  • Female