An optically transparent membrane supports shear stress studies in a three-dimensional microfluidic neurovascular unit model.
Publication
, Journal Article
Sellgren, KL; Hawkins, BT; Grego, S
Published in: Biomicrofluidics
November 2015
We report a microfluidic blood-brain barrier model that enables both physiological shear stress and optical transparency throughout the device. Brain endothelial cells grown in an optically transparent membrane-integrated microfluidic device were able to withstand physiological fluid shear stress using a hydrophilized polytetrafluoroethylene nanoporous membrane instead of the more commonly used polyester membrane. A functional three-dimensional microfluidic co-culture model of the neurovascular unit is presented that incorporates astrocytes in a 3D hydrogel and enables physiological shear stress on the membrane-supported endothelial cell layer.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Biomicrofluidics
DOI
EISSN
1932-1058
ISSN
1932-1058
Publication Date
November 2015
Volume
9
Issue
6
Start / End Page
061102
Related Subject Headings
- Nanoscience & Nanotechnology
- 4012 Fluid mechanics and thermal engineering
- 1007 Nanotechnology
- 0915 Interdisciplinary Engineering
- 0203 Classical Physics
Citation
APA
Chicago
ICMJE
MLA
NLM
Sellgren, K. L., Hawkins, B. T., & Grego, S. (2015). An optically transparent membrane supports shear stress studies in a three-dimensional microfluidic neurovascular unit model. Biomicrofluidics, 9(6), 061102. https://doi.org/10.1063/1.4935594
Sellgren, Katelyn L., Brian T. Hawkins, and Sonia Grego. “An optically transparent membrane supports shear stress studies in a three-dimensional microfluidic neurovascular unit model.” Biomicrofluidics 9, no. 6 (November 2015): 061102. https://doi.org/10.1063/1.4935594.
Sellgren KL, Hawkins BT, Grego S. An optically transparent membrane supports shear stress studies in a three-dimensional microfluidic neurovascular unit model. Biomicrofluidics. 2015 Nov;9(6):061102.
Sellgren, Katelyn L., et al. “An optically transparent membrane supports shear stress studies in a three-dimensional microfluidic neurovascular unit model.” Biomicrofluidics, vol. 9, no. 6, Nov. 2015, p. 061102. Epmc, doi:10.1063/1.4935594.
Sellgren KL, Hawkins BT, Grego S. An optically transparent membrane supports shear stress studies in a three-dimensional microfluidic neurovascular unit model. Biomicrofluidics. 2015 Nov;9(6):061102.
Published In
Biomicrofluidics
DOI
EISSN
1932-1058
ISSN
1932-1058
Publication Date
November 2015
Volume
9
Issue
6
Start / End Page
061102
Related Subject Headings
- Nanoscience & Nanotechnology
- 4012 Fluid mechanics and thermal engineering
- 1007 Nanotechnology
- 0915 Interdisciplinary Engineering
- 0203 Classical Physics