Skip to main content

Catheter-directed gastric artery chemical embolization for modulation of systemic ghrelin levels in a porcine model: initial experience.

Publication ,  Journal Article
Arepally, A; Barnett, BP; Montgomery, E; Patel, TH
Published in: Radiology
July 2007

To prospectively test, in a porcine model, the hypothesis that use of catheter-directed gastric artery chemical embolization (GACE) can result in substantial suppression of systemic ghrelin levels.The institutional animal care and use committee approved this study. Adult healthy swine (40-45 kg, n=8) were tested. GACE was performed by infusing morrhuate sodium selectively into the left gastric artery. Six swine (animals A-F) underwent left GACE by using a dose-escalating regimen of morrhuate sodium, whereas two control swine underwent a sham procedure. Weight and fasting plasma ghrelin levels were compared in swine at baseline and at weeks 1-4. At week 4, stomachs were excised and analyzed. Analysis of the change in ghrelin values and weight was performed with both paired t test and unpaired Student t test.In control swine (n=2), there was no significant difference in ghrelin values before (844.8 pg/mL +/- 40 [standard deviation]) and after (997 pg/mL +/- 93) the procedure (P=.5). Swine that received a low dose of morrhuate sodium (animals A-D) showed a significant increase in serum ghrelin values from 683.7 pg/mL +/- 241 to 1555.9 pg/mL +/- 312 (P=.002). At a higher dose, the mean baseline ghrelin values decreased from 466 pg/mL to 187 pg/mL +/- 162. Weight changes of +1.4% and +8.6% were seen in swine that underwent GACE and control swine, respectively. Histochemical staining showed preservation of overall tissue architecture and parietal cells.Use of GACE can result in increased or suppressed ghrelin levels.

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Radiology

DOI

EISSN

1527-1315

ISSN

0033-8419

Publication Date

July 2007

Volume

244

Issue

1

Start / End Page

138 / 143

Related Subject Headings

  • Swine
  • Stomach
  • Sodium Morrhuate
  • Sclerosing Solutions
  • Prospective Studies
  • Pilot Projects
  • Peptide Hormones
  • Nuclear Medicine & Medical Imaging
  • Immunohistochemistry
  • Ghrelin
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Arepally, A., Barnett, B. P., Montgomery, E., & Patel, T. H. (2007). Catheter-directed gastric artery chemical embolization for modulation of systemic ghrelin levels in a porcine model: initial experience. Radiology, 244(1), 138–143. https://doi.org/10.1148/radiol.2441060790
Arepally, Aravind, Brad P. Barnett, Elizabeth Montgomery, and Tarak H. Patel. “Catheter-directed gastric artery chemical embolization for modulation of systemic ghrelin levels in a porcine model: initial experience.Radiology 244, no. 1 (July 2007): 138–43. https://doi.org/10.1148/radiol.2441060790.
Arepally, Aravind, et al. “Catheter-directed gastric artery chemical embolization for modulation of systemic ghrelin levels in a porcine model: initial experience.Radiology, vol. 244, no. 1, July 2007, pp. 138–43. Epmc, doi:10.1148/radiol.2441060790.

Published In

Radiology

DOI

EISSN

1527-1315

ISSN

0033-8419

Publication Date

July 2007

Volume

244

Issue

1

Start / End Page

138 / 143

Related Subject Headings

  • Swine
  • Stomach
  • Sodium Morrhuate
  • Sclerosing Solutions
  • Prospective Studies
  • Pilot Projects
  • Peptide Hormones
  • Nuclear Medicine & Medical Imaging
  • Immunohistochemistry
  • Ghrelin