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Magnetic resonance-guided, real-time targeted delivery and imaging of magnetocapsules immunoprotecting pancreatic islet cells.

Publication ,  Journal Article
Barnett, BP; Arepally, A; Karmarkar, PV; Qian, D; Gilson, WD; Walczak, P; Howland, V; Lawler, L; Lauzon, C; Stuber, M; Kraitchman, DL; Bulte, JWM
Published in: Nature medicine
August 2007

In type I diabetes mellitus, islet transplantation provides a moment-to-moment fine regulation of insulin. Success rates vary widely, however, necessitating suitable methods to monitor islet delivery, engraftment and survival. Here magnetic resonance-trackable magnetocapsules have been used simultaneously to immunoprotect pancreatic beta-cells and to monitor, non-invasively in real-time, hepatic delivery and engraftment by magnetic resonance imaging (MRI). Magnetocapsules were detected as single capsules with an altered magnetic resonance appearance on capsule rupture. Magnetocapsules were functional in vivo because mouse beta-cells restored normal glycemia in streptozotocin-induced diabetic mice and human islets induced sustained C-peptide levels in swine. In this large-animal model, magnetocapsules could be precisely targeted for infusion by using magnetic resonance fluoroscopy, whereas MRI facilitated monitoring of liver engraftment over time. These findings are directly applicable to ongoing improvements in islet cell transplantation for human diabetes, particularly because our magnetocapsules comprise clinically applicable materials.

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Published In

Nature medicine

DOI

EISSN

1546-170X

ISSN

1078-8956

Publication Date

August 2007

Volume

13

Issue

8

Start / End Page

986 / 991

Related Subject Headings

  • Time Factors
  • Swine
  • Mice
  • Magnetics
  • Magnetic Resonance Imaging
  • Islets of Langerhans Transplantation
  • Islets of Langerhans
  • Immunosuppressive Agents
  • Immunology
  • Humans
 

Citation

APA
Chicago
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Barnett, B. P., Arepally, A., Karmarkar, P. V., Qian, D., Gilson, W. D., Walczak, P., … Bulte, J. W. M. (2007). Magnetic resonance-guided, real-time targeted delivery and imaging of magnetocapsules immunoprotecting pancreatic islet cells. Nature Medicine, 13(8), 986–991. https://doi.org/10.1038/nm1581
Barnett, Brad P., Aravind Arepally, Parag V. Karmarkar, Di Qian, Wesley D. Gilson, Piotr Walczak, Valerie Howland, et al. “Magnetic resonance-guided, real-time targeted delivery and imaging of magnetocapsules immunoprotecting pancreatic islet cells.Nature Medicine 13, no. 8 (August 2007): 986–91. https://doi.org/10.1038/nm1581.
Barnett BP, Arepally A, Karmarkar PV, Qian D, Gilson WD, Walczak P, et al. Magnetic resonance-guided, real-time targeted delivery and imaging of magnetocapsules immunoprotecting pancreatic islet cells. Nature medicine. 2007 Aug;13(8):986–91.
Barnett, Brad P., et al. “Magnetic resonance-guided, real-time targeted delivery and imaging of magnetocapsules immunoprotecting pancreatic islet cells.Nature Medicine, vol. 13, no. 8, Aug. 2007, pp. 986–91. Epmc, doi:10.1038/nm1581.
Barnett BP, Arepally A, Karmarkar PV, Qian D, Gilson WD, Walczak P, Howland V, Lawler L, Lauzon C, Stuber M, Kraitchman DL, Bulte JWM. Magnetic resonance-guided, real-time targeted delivery and imaging of magnetocapsules immunoprotecting pancreatic islet cells. Nature medicine. 2007 Aug;13(8):986–991.

Published In

Nature medicine

DOI

EISSN

1546-170X

ISSN

1078-8956

Publication Date

August 2007

Volume

13

Issue

8

Start / End Page

986 / 991

Related Subject Headings

  • Time Factors
  • Swine
  • Mice
  • Magnetics
  • Magnetic Resonance Imaging
  • Islets of Langerhans Transplantation
  • Islets of Langerhans
  • Immunosuppressive Agents
  • Immunology
  • Humans