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The current state of immunotherapy for gliomas: an eye toward the future.

Publication ,  Journal Article
Fecci, PE; Sampson, JH
Published in: J Neurosurg
September 1, 2019

The last decade has seen a crescendo of FDA approvals for immunotherapies against solid tumors, yet glioblastoma remains a prominent holdout. Despite more than 4 decades of work with a wide range of immunotherapeutic modalities targeting glioblastoma, efficacy has been challenging to obtain. Earlier forms of immune-based platforms have now given way to more current approaches, including chimeric antigen receptor T-cells, personalized neoantigen vaccines, oncolytic viruses, and checkpoint blockade. The recent experiences with each, as well as the latest developments and anticipated challenges, are reviewed.

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Published In

J Neurosurg

DOI

EISSN

1933-0693

Publication Date

September 1, 2019

Volume

131

Issue

3

Start / End Page

657 / 666

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Neurology & Neurosurgery
  • Immunotherapy
  • Humans
  • Glioma
  • Glioblastoma
  • Cancer Vaccines
  • Brain Neoplasms
  • Animals
  • 3209 Neurosciences
 

Citation

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Fecci, P. E., & Sampson, J. H. (2019). The current state of immunotherapy for gliomas: an eye toward the future. J Neurosurg, 131(3), 657–666. https://doi.org/10.3171/2019.5.JNS181762
Fecci, Peter E., and John H. Sampson. “The current state of immunotherapy for gliomas: an eye toward the future.J Neurosurg 131, no. 3 (September 1, 2019): 657–66. https://doi.org/10.3171/2019.5.JNS181762.
Fecci PE, Sampson JH. The current state of immunotherapy for gliomas: an eye toward the future. J Neurosurg. 2019 Sep 1;131(3):657–66.
Fecci, Peter E., and John H. Sampson. “The current state of immunotherapy for gliomas: an eye toward the future.J Neurosurg, vol. 131, no. 3, Sept. 2019, pp. 657–66. Pubmed, doi:10.3171/2019.5.JNS181762.
Fecci PE, Sampson JH. The current state of immunotherapy for gliomas: an eye toward the future. J Neurosurg. 2019 Sep 1;131(3):657–666.

Published In

J Neurosurg

DOI

EISSN

1933-0693

Publication Date

September 1, 2019

Volume

131

Issue

3

Start / End Page

657 / 666

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Neurology & Neurosurgery
  • Immunotherapy
  • Humans
  • Glioma
  • Glioblastoma
  • Cancer Vaccines
  • Brain Neoplasms
  • Animals
  • 3209 Neurosciences