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Perioperative changes in prouroguanylin hormone response in severely obese subjects after bariatric surgery.

Publication ,  Journal Article
Torquati, A; Shantavasinkul, PC; Omotosho, P; Corsino, L; Spagnoli, A
Published in: Surgery
October 2019

BACKGROUND: Prouroguanylin is a gut hormone converted into uroguanylin in the hypothalamus. Uroguanylin induces satiety through guanylyl-cyclase-2C receptor signaling. However, little is known about the role of this hormone in regulating human food intake. METHODS: In prospective-cohort study, prouroguanylin profile changes were determined during meal stimulation in obese patients 2 weeks before and 2 weeks after Roux-en-Y gastric bypass surgery. We also investigated whether these changes play a role in the anorexigenic effect of Roux-en-Y gastric bypass. RESULTS: The study enrolled 8 healthy lean volunteers and 10 obese patients with type 2 diabetes. Prouroguanylin levels were postprandially decreased at 30 minutes (P = .04) and 60 minutes (P = .008) in obese patients before surgery, and they were increased at 60 minutes (P = .003), 90 minutes (P = .008), and 120 minutes (P = .009) after surgery. We observed a significant difference (P = .001) in fasting prouroguanylin levels before (8.82 ± 1.2 ng/mL) and after (6.05 ± 1.2 ng/mL) Roux-en-Y gastric bypass. Hunger ratings in the fasted state did not change after Roux-en-Y gastric bypass. Instead, subjects demonstrated significantly (P = .01) lower hunger visual analog scale scores than before Roux-en-Y gastric bypass. No correlations between circulating prouroguanylin levels and hunger perception were found before or after Roux-en-Y gastric bypass. CONCLUSION: Prouroguanylin levels decrease after meal stimulation in obese patients, and they increase after Roux-en-Y gastric bypass, but no correlations exist with hunger visual analog scale scores.

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Published In

Surgery

DOI

EISSN

1532-7361

Publication Date

October 2019

Volume

166

Issue

4

Start / End Page

456 / 459

Location

United States

Related Subject Headings

  • Weight Loss
  • Treatment Outcome
  • Surgery
  • Protein Precursors
  • Prospective Studies
  • Preoperative Period
  • Postoperative Period
  • Obesity, Morbid
  • Middle Aged
  • Male
 

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ICMJE
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Torquati, A., Shantavasinkul, P. C., Omotosho, P., Corsino, L., & Spagnoli, A. (2019). Perioperative changes in prouroguanylin hormone response in severely obese subjects after bariatric surgery. Surgery, 166(4), 456–459. https://doi.org/10.1016/j.surg.2019.06.037
Torquati, Alfonso, Prapimporn Chattranukulchai Shantavasinkul, Philip Omotosho, Leonor Corsino, and Anna Spagnoli. “Perioperative changes in prouroguanylin hormone response in severely obese subjects after bariatric surgery.Surgery 166, no. 4 (October 2019): 456–59. https://doi.org/10.1016/j.surg.2019.06.037.
Torquati A, Shantavasinkul PC, Omotosho P, Corsino L, Spagnoli A. Perioperative changes in prouroguanylin hormone response in severely obese subjects after bariatric surgery. Surgery. 2019 Oct;166(4):456–9.
Torquati, Alfonso, et al. “Perioperative changes in prouroguanylin hormone response in severely obese subjects after bariatric surgery.Surgery, vol. 166, no. 4, Oct. 2019, pp. 456–59. Pubmed, doi:10.1016/j.surg.2019.06.037.
Torquati A, Shantavasinkul PC, Omotosho P, Corsino L, Spagnoli A. Perioperative changes in prouroguanylin hormone response in severely obese subjects after bariatric surgery. Surgery. 2019 Oct;166(4):456–459.
Journal cover image

Published In

Surgery

DOI

EISSN

1532-7361

Publication Date

October 2019

Volume

166

Issue

4

Start / End Page

456 / 459

Location

United States

Related Subject Headings

  • Weight Loss
  • Treatment Outcome
  • Surgery
  • Protein Precursors
  • Prospective Studies
  • Preoperative Period
  • Postoperative Period
  • Obesity, Morbid
  • Middle Aged
  • Male