Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans.
Publication
, Journal Article
Warchol, ME; Lambert, PR; Goldstein, BJ; Forge, A; Corwin, JT
Published in: Science
March 12, 1993
Supporting cells in the vestibular sensory epithelia from the ears of mature guinea pigs and adult humans proliferate in vitro after treatments with aminoglycoside antibiotics that cause sensory hair cells to die. After 4 weeks in culture, the epithelia contained new cells with some characteristics of immature hair cells. These findings are in contrast to expectations based on previous studies, which had suggested that hair cell loss is irreversible in mammals. The loss of hair cells is responsible for hearing and balance deficits that affect millions of people.
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Published In
Science
DOI
ISSN
0036-8075
Publication Date
March 12, 1993
Volume
259
Issue
5101
Start / End Page
1619 / 1622
Location
United States
Related Subject Headings
- Thymidine
- Saccule and Utricle
- Regeneration
- Neomycin
- Humans
- Hair Cells, Auditory
- Guinea Pigs
- Gentamicins
- General Science & Technology
- Epithelium
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APA
Chicago
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MLA
NLM
Warchol, M. E., Lambert, P. R., Goldstein, B. J., Forge, A., & Corwin, J. T. (1993). Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans. Science, 259(5101), 1619–1622. https://doi.org/10.1126/science.8456285
Warchol, M. E., P. R. Lambert, B. J. Goldstein, A. Forge, and J. T. Corwin. “Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans.” Science 259, no. 5101 (March 12, 1993): 1619–22. https://doi.org/10.1126/science.8456285.
Warchol ME, Lambert PR, Goldstein BJ, Forge A, Corwin JT. Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans. Science. 1993 Mar 12;259(5101):1619–22.
Warchol, M. E., et al. “Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans.” Science, vol. 259, no. 5101, Mar. 1993, pp. 1619–22. Pubmed, doi:10.1126/science.8456285.
Warchol ME, Lambert PR, Goldstein BJ, Forge A, Corwin JT. Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans. Science. 1993 Mar 12;259(5101):1619–1622.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
March 12, 1993
Volume
259
Issue
5101
Start / End Page
1619 / 1622
Location
United States
Related Subject Headings
- Thymidine
- Saccule and Utricle
- Regeneration
- Neomycin
- Humans
- Hair Cells, Auditory
- Guinea Pigs
- Gentamicins
- General Science & Technology
- Epithelium