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The effect of MLC leaf width in single-isocenter multi-target radiosurgery with volumetric modulated arc therapy.

Publication ,  Journal Article
Abisheva, Z; Floyd, SR; Salama, JK; Kirkpatrick, J; Yin, F-F; Moravan, MJ; Giles, W; Adamson, J
Published in: J Radiosurg SBRT
2019

PURPOSE: Single-isocenter multi-target (SIMT) volumetric modulated arc therapy (VMAT) is primarily limited to linear accelerators utilizing 2.5 mm leaf width MLCs. We explore feasibility of applying this technique to linear accelerators utilizing MLCs with leaf width of 5 mm. METHODS: Twenty patients with 3-10 intracranial brain metastases originally treated with 2.5 mm MLCs were re-planned using 5 mm MLCs and relevant dosimetric indices were compared. We also evaluated various strategies of adding VMAT arcs to mitigate degradations of dose quality values. RESULTS: Wider MLCs caused small changes in total MUs (5827 ± 2334 vs 5572 ± 2220, p = 0.006), and conformity index (CI) (2.22% ± 0.05%, p = 0.045), but produced more substantial increases in brain V30%[%] and V50%[%] (27.75% ± 0.16% and 20.04% ± 0.13% respectively, p < 0.001 for both), and V12Gy[cc] (16.91% ± 0.12%, p < 0.001). CONCLUSION: SIMT radiosurgery delivered via VMAT using 5 mm wide MLCs can achieve similar CI compared to that using 2.5 mm leaf width MLCs but with moderately increased isodose spill, which can be only partially mitigated by increasing the number of VMAT arcs.

Duke Scholars

Published In

J Radiosurg SBRT

EISSN

2156-4647

Publication Date

2019

Volume

6

Issue

2

Start / End Page

131 / 138

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Abisheva, Z., Floyd, S. R., Salama, J. K., Kirkpatrick, J., Yin, F.-F., Moravan, M. J., … Adamson, J. (2019). The effect of MLC leaf width in single-isocenter multi-target radiosurgery with volumetric modulated arc therapy. J Radiosurg SBRT, 6(2), 131–138.
Abisheva, Zhanerke, Scott R. Floyd, Joseph K. Salama, John Kirkpatrick, Fang-Fang Yin, Michael J. Moravan, William Giles, and Justus Adamson. “The effect of MLC leaf width in single-isocenter multi-target radiosurgery with volumetric modulated arc therapy.J Radiosurg SBRT 6, no. 2 (2019): 131–38.
Abisheva Z, Floyd SR, Salama JK, Kirkpatrick J, Yin F-F, Moravan MJ, et al. The effect of MLC leaf width in single-isocenter multi-target radiosurgery with volumetric modulated arc therapy. J Radiosurg SBRT. 2019;6(2):131–8.
Abisheva, Zhanerke, et al. “The effect of MLC leaf width in single-isocenter multi-target radiosurgery with volumetric modulated arc therapy.J Radiosurg SBRT, vol. 6, no. 2, 2019, pp. 131–38.
Abisheva Z, Floyd SR, Salama JK, Kirkpatrick J, Yin F-F, Moravan MJ, Giles W, Adamson J. The effect of MLC leaf width in single-isocenter multi-target radiosurgery with volumetric modulated arc therapy. J Radiosurg SBRT. 2019;6(2):131–138.

Published In

J Radiosurg SBRT

EISSN

2156-4647

Publication Date

2019

Volume

6

Issue

2

Start / End Page

131 / 138

Location

United States