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Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology.

Publication ,  Journal Article
Barupal, DK; Baillie, R; Fan, S; Saykin, AJ; Meikle, PJ; Arnold, M; Nho, K; Fiehn, O; Kaddurah-Daouk, R; Alzheimer Disease Metabolomics Consortium,
Published in: Alzheimers Dement (Amst)
December 2019

INTRODUCTION: Comorbidity with metabolic diseases indicates that lipid metabolism plays a role in the etiology of Alzheimer's disease (AD). Comprehensive lipidomic analysis can provide new insights into the altered lipid metabolism in AD. METHOD: In this study, a total 349 serum lipids were measured in 806 participants enrolled in the Alzheimer's Disease Neuroimaging Initiative Phase 1 cohort and analyzed using lipid-set enrichment statistics, a data mining method to find coregulated lipid sets. RESULTS: We found that sets of blood lipids were associated with current AD biomarkers and with AD clinical symptoms. AD diagnosis was associated with 7 of 28 lipid sets of which four also correlated with cognitive decline, including polyunsaturated fatty acids. Cerebrospinal fluid amyloid beta (Aβ1-42) correlated with glucosylceramides, lysophosphatidylcholines and unsaturated triacylglycerides; cerebrospinal fluid total tau and brain atrophy correlated with monounsaturated sphingomyelins and ceramides, in addition to EPA-containing lipids. DISCUSSION: AD-associated lipid sets indicated that lipid desaturation, elongation, and acyl chain remodeling processes are disturbed in AD subjects. Monounsaturated lipid metabolism was important in early stages of AD, whereas the polyunsaturated lipid metabolism was associated with later stages of AD. Our study provides several new hypotheses for studying the role of lipid metabolism in AD.

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Published In

Alzheimers Dement (Amst)

DOI

ISSN

2352-8729

Publication Date

December 2019

Volume

11

Start / End Page

619 / 627

Location

United States

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1109 Neurosciences
  • 0604 Genetics
 

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ICMJE
MLA
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Barupal, D. K., Baillie, R., Fan, S., Saykin, A. J., Meikle, P. J., Arnold, M., … Alzheimer Disease Metabolomics Consortium, . (2019). Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology. Alzheimers Dement (Amst), 11, 619–627. https://doi.org/10.1016/j.dadm.2019.07.002
Barupal, Dinesh Kumar, Rebecca Baillie, Sili Fan, Andrew J. Saykin, Peter J. Meikle, Matthias Arnold, Kwangsik Nho, Oliver Fiehn, Rima Kaddurah-Daouk, and Rima Alzheimer Disease Metabolomics Consortium. “Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology.Alzheimers Dement (Amst) 11 (December 2019): 619–27. https://doi.org/10.1016/j.dadm.2019.07.002.
Barupal DK, Baillie R, Fan S, Saykin AJ, Meikle PJ, Arnold M, et al. Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology. Alzheimers Dement (Amst). 2019 Dec;11:619–27.
Barupal, Dinesh Kumar, et al. “Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology.Alzheimers Dement (Amst), vol. 11, Dec. 2019, pp. 619–27. Pubmed, doi:10.1016/j.dadm.2019.07.002.
Barupal DK, Baillie R, Fan S, Saykin AJ, Meikle PJ, Arnold M, Nho K, Fiehn O, Kaddurah-Daouk R, Alzheimer Disease Metabolomics Consortium. Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology. Alzheimers Dement (Amst). 2019 Dec;11:619–627.
Journal cover image

Published In

Alzheimers Dement (Amst)

DOI

ISSN

2352-8729

Publication Date

December 2019

Volume

11

Start / End Page

619 / 627

Location

United States

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1109 Neurosciences
  • 0604 Genetics