The expanded role of fatty acid metabolism in cancer: new aspects and targets.
Publication
, Journal Article
Chen, M; Huang, J
Published in: Precis Clin Med
September 2019
Cancer cells undergo metabolic reprogramming to support cell proliferation, growth, and dissemination. Alterations in lipid metabolism, and specifically the uptake and synthesis of fatty acids (FAs), comprise one well-documented aspect of this reprogramming. Recent studies have revealed an expanded range of roles played by FA in promoting the aggressiveness of cancer while simultaneously identifying new potential targets for cancer therapy. This article provides a brief review of these advances in our understanding of FA metabolism in cancer, highlighting both recent discoveries and the inherent challenges caused by the metabolic plasticity of cancer cells in targeting lipid metabolism for cancer therapy.
Duke Scholars
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Published In
Precis Clin Med
DOI
EISSN
2516-1571
Publication Date
September 2019
Volume
2
Issue
3
Start / End Page
183 / 191
Location
England
Citation
APA
Chicago
ICMJE
MLA
NLM
Chen, M., & Huang, J. (2019). The expanded role of fatty acid metabolism in cancer: new aspects and targets. Precis Clin Med, 2(3), 183–191. https://doi.org/10.1093/pcmedi/pbz017
Chen, Ming, and Jiaoti Huang. “The expanded role of fatty acid metabolism in cancer: new aspects and targets.” Precis Clin Med 2, no. 3 (September 2019): 183–91. https://doi.org/10.1093/pcmedi/pbz017.
Chen M, Huang J. The expanded role of fatty acid metabolism in cancer: new aspects and targets. Precis Clin Med. 2019 Sep;2(3):183–91.
Chen, Ming, and Jiaoti Huang. “The expanded role of fatty acid metabolism in cancer: new aspects and targets.” Precis Clin Med, vol. 2, no. 3, Sept. 2019, pp. 183–91. Pubmed, doi:10.1093/pcmedi/pbz017.
Chen M, Huang J. The expanded role of fatty acid metabolism in cancer: new aspects and targets. Precis Clin Med. 2019 Sep;2(3):183–191.
Published In
Precis Clin Med
DOI
EISSN
2516-1571
Publication Date
September 2019
Volume
2
Issue
3
Start / End Page
183 / 191
Location
England