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Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential.

Publication ,  Journal Article
Allen, TA; Asad, D; Amu, E; Hensley, MT; Cores, J; Vandergriff, A; Tang, J; Dinh, P-U; Shen, D; Qiao, L; Su, T; Hu, S; Liang, H; Shive, H ...
Published in: J Cell Sci
September 9, 2019

Metastasis accounts for the majority of all cancer deaths, yet the process remains poorly understood. A pivotal step in the metastasis process is the exiting of tumor cells from the circulation, a process known as extravasation. However, it is unclear how tumor cells extravasate and whether multicellular clusters of tumor cells possess the ability to exit as a whole or must first disassociate. In this study, we use in vivo zebrafish and mouse models to elucidate the mechanism tumor cells use to extravasate. We found that circulating tumor cells exit the circulation using the recently identified extravasation mechanism, angiopellosis, and do so as both clusters and individual cells. We further show that when melanoma and cervical cancer cells utilize this extravasation method to exit as clusters, they exhibit an increased ability to form tumors at distant sites through the expression of unique genetic profiles. Collectively, we present a new model for tumor cell extravasation of both individual and multicellular circulating tumor cells.This article has an associated First Person interview with the first author of the paper.

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Published In

J Cell Sci

DOI

EISSN

1477-9137

Publication Date

September 9, 2019

Volume

132

Issue

17

Location

England

Related Subject Headings

  • Neoplastic Cells, Circulating
  • Neoplasm Metastasis
  • Mice
  • Humans
  • Hela Cells
  • HeLa Cells
  • Developmental Biology
  • Cell Movement
  • Cell Count
  • Animals
 

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Allen, T. A., Asad, D., Amu, E., Hensley, M. T., Cores, J., Vandergriff, A., … Cheng, K. (2019). Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential. J Cell Sci, 132(17). https://doi.org/10.1242/jcs.231563
Allen, Tyler A., Dana Asad, Emmanuel Amu, M Taylor Hensley, Jhon Cores, Adam Vandergriff, Junnan Tang, et al. “Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential.J Cell Sci 132, no. 17 (September 9, 2019). https://doi.org/10.1242/jcs.231563.
Allen TA, Asad D, Amu E, Hensley MT, Cores J, Vandergriff A, et al. Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential. J Cell Sci. 2019 Sep 9;132(17).
Allen, Tyler A., et al. “Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential.J Cell Sci, vol. 132, no. 17, Sept. 2019. Pubmed, doi:10.1242/jcs.231563.
Allen TA, Asad D, Amu E, Hensley MT, Cores J, Vandergriff A, Tang J, Dinh P-U, Shen D, Qiao L, Su T, Hu S, Liang H, Shive H, Harrell E, Campbell C, Peng X, Yoder JA, Cheng K. Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential. J Cell Sci. 2019 Sep 9;132(17).
Journal cover image

Published In

J Cell Sci

DOI

EISSN

1477-9137

Publication Date

September 9, 2019

Volume

132

Issue

17

Location

England

Related Subject Headings

  • Neoplastic Cells, Circulating
  • Neoplasm Metastasis
  • Mice
  • Humans
  • Hela Cells
  • HeLa Cells
  • Developmental Biology
  • Cell Movement
  • Cell Count
  • Animals