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Evaluation of Intraindividual Contrast Enhancement Variability for Determining the Maximum Achievable Consistency in CT.

Publication ,  Journal Article
Johnson, DY; Farjat, AE; Vernuccio, F; Hurwitz, LM; Nelson, RC; Marin, D
Published in: AJR Am J Roentgenol
January 2020

OBJECTIVE. The purpose of this study was to quantify temporal variability in vascular and parenchymal enhancement within the same patient and to determine technique-related factors contributing to this variability. MATERIALS AND METHODS. We identified 100 patients who underwent four CT scans within 12 months with identical acquisition and contrast injection parameters. Enhancement was recorded in the abdominal aorta, main portal vein, liver parenchyma, and subcutaneous fat. Patient demographic and body habitus data were recorded. Injection-related factors were recorded including delay time from contrast injection to image acquisition. All pairwise differences in enhancement within each patient were evaluated for absolute and percentage change. RESULTS. Based on predetermined thresholds, we observed clinically relevant variability in 34% of patients for the abdominal aorta, 38% for the portal vein, and 33% for the liver parenchyma. A highly significant association was observed between higher variability in delay time and variability in the abdominal aorta (p = 0.009) and between female sex and variability in liver parenchyma (p = 0.008). A marginally significant association was seen between increasing age (p = 0.025) and female sex (p = 0.039) with variability in the abdominal aorta. No statistically significant association was found between all recorded variables and variability in the portal vein. CONCLUSION. Approximately one-third of patients may show clinically relevant variability in enhancement of the abdominal aorta, portal vein, and liver parenchyma even when using identical scanning and injection parameters. Delay time was the only controllable factor associated with variability in enhancement of the abdominal aorta; no other controllable factor is associated with variability in the portal vein or liver parenchyma.

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Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

January 2020

Volume

214

Issue

1

Start / End Page

18 / 23

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Time Factors
  • Subcutaneous Fat, Abdominal
  • Retrospective Studies
  • Radiographic Image Enhancement
  • Portal Vein
  • Observer Variation
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
 

Citation

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Johnson, D. Y., Farjat, A. E., Vernuccio, F., Hurwitz, L. M., Nelson, R. C., & Marin, D. (2020). Evaluation of Intraindividual Contrast Enhancement Variability for Determining the Maximum Achievable Consistency in CT. AJR Am J Roentgenol, 214(1), 18–23. https://doi.org/10.2214/AJR.19.21628
Johnson, David Y., Alfredo E. Farjat, Federica Vernuccio, Lynne M. Hurwitz, Rendon C. Nelson, and Daniele Marin. “Evaluation of Intraindividual Contrast Enhancement Variability for Determining the Maximum Achievable Consistency in CT.AJR Am J Roentgenol 214, no. 1 (January 2020): 18–23. https://doi.org/10.2214/AJR.19.21628.
Johnson DY, Farjat AE, Vernuccio F, Hurwitz LM, Nelson RC, Marin D. Evaluation of Intraindividual Contrast Enhancement Variability for Determining the Maximum Achievable Consistency in CT. AJR Am J Roentgenol. 2020 Jan;214(1):18–23.
Johnson, David Y., et al. “Evaluation of Intraindividual Contrast Enhancement Variability for Determining the Maximum Achievable Consistency in CT.AJR Am J Roentgenol, vol. 214, no. 1, Jan. 2020, pp. 18–23. Pubmed, doi:10.2214/AJR.19.21628.
Johnson DY, Farjat AE, Vernuccio F, Hurwitz LM, Nelson RC, Marin D. Evaluation of Intraindividual Contrast Enhancement Variability for Determining the Maximum Achievable Consistency in CT. AJR Am J Roentgenol. 2020 Jan;214(1):18–23.

Published In

AJR Am J Roentgenol

DOI

EISSN

1546-3141

Publication Date

January 2020

Volume

214

Issue

1

Start / End Page

18 / 23

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Time Factors
  • Subcutaneous Fat, Abdominal
  • Retrospective Studies
  • Radiographic Image Enhancement
  • Portal Vein
  • Observer Variation
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male