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Vitamin D supplementation augments SIgA secretion rates in Marine Corps basic trainees

Publication ,  Conference
Scott, J; Gaffney-Stomberg, E; Palmer, J; Daigle, R; Kazman, J; McClung, J; Gasier, H

BACKGROUND: Vitamin D has been implicated in modulating innate immunity and may confer protection against upper respiratory tract infections (URTIs) during periods of arduous training. PURPOSE: Determine whether vitamin D status in Marine Corps basic training recruits is associated with URTIs, and whether daily vitamin D supplementation decreases the incidence of URTIs as a result of augmented innate immunity. METHODS: A double-blind RCT was conducted with male and female recruits entering Marine Corps basic training. Subjects were randomized to either 1000 IU vitamin D3·d-1 (n=73) or placebo (n=76) for 12-weeks. At baseline, weeks 4, 8 and 12 (post-training) subjects provided saliva samples (passive drool) to determine secretory immunoglobulin A secretion rates (SIgA-SR) by indirect ELISA. The incidence of URTIs was assessed by administering a survey at weeks 4, 8 and 12. Serum vitamin D status (25(OH)D) was measured by radioimmunoassay. Longitudinal linear models were created using a simple-effects model to estimate symptoms. To determine whether supplementation altered SIgA-SR during training, a two-way repeated measures ANOVA was used. RESULTS: The proportion of recruits reporting URTI symptoms at any time during training was 72%. Baseline SIgA-SR were similar between placebo (65.4 ± 52.0 μg·min-1) and vitamin D groups (51.9 ± 41.9 μg·min-1). The relative changes in SIgA-SR were significantly greater with vitamin D supplementation at weeks 4 (5.1 ± 29.8%) and 8 (12.3 ± 31.0%) compared to placebo at the same time points (week 4; -6.5 ± 22.9% and week 8; 1.3 ± 22.9%), p = 0.001. Baseline 25(OH)D was significantly lower during winter (59.2 ± 22.5 nmol·L-1) compared to summer (80.4 ± 21.0 nmol·L-1), p < 0.001. When accounting for treatment, season and sex, there was no association between 25(OH)D and reported URTIs. CONCLUSION: We report that a high proportion of Marine Corps recruits experience URTIs during 12-weeks of basic military training, and although daily vitamin D supplementation led to a modest increase in SIgA-SR, this did not result in a reduction in the incidence of reported URTIs.

Duke Scholars

DOI

Volume

49

Issue

5S

Location

Denver, CO

Publisher

Ovid Technologies (Wolters Kluwer Health)

Conference Name

American College of Sports Medicine

Related Subject Headings

  • Sport Sciences
  • 1117 Public Health and Health Services
  • 1116 Medical Physiology
  • 1106 Human Movement and Sports Sciences
 

Citation

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Scott, J., Gaffney-Stomberg, E., Palmer, J., Daigle, R., Kazman, J., McClung, J., & Gasier, H. (n.d.). Vitamin D supplementation augments SIgA secretion rates in Marine Corps basic trainees (Vol. 49). Presented at the American College of Sports Medicine, Denver, CO: Ovid Technologies (Wolters Kluwer Health). https://doi.org/10.1249/01.mss.0000517091.38477.62
Scott, Jonathan, Erin Gaffney-Stomberg, Jeremy Palmer, Ryan Daigle, Josh Kazman, James McClung, and Heath Gasier. “Vitamin D supplementation augments SIgA secretion rates in Marine Corps basic trainees,” Vol. 49. Ovid Technologies (Wolters Kluwer Health), n.d. https://doi.org/10.1249/01.mss.0000517091.38477.62.
Scott J, Gaffney-Stomberg E, Palmer J, Daigle R, Kazman J, McClung J, et al. Vitamin D supplementation augments SIgA secretion rates in Marine Corps basic trainees. In Ovid Technologies (Wolters Kluwer Health);
Scott, Jonathan, et al. Vitamin D supplementation augments SIgA secretion rates in Marine Corps basic trainees. Vol. 49, no. 5S, Ovid Technologies (Wolters Kluwer Health). Manual, doi:10.1249/01.mss.0000517091.38477.62.
Scott J, Gaffney-Stomberg E, Palmer J, Daigle R, Kazman J, McClung J, Gasier H. Vitamin D supplementation augments SIgA secretion rates in Marine Corps basic trainees. Ovid Technologies (Wolters Kluwer Health);

DOI

Volume

49

Issue

5S

Location

Denver, CO

Publisher

Ovid Technologies (Wolters Kluwer Health)

Conference Name

American College of Sports Medicine

Related Subject Headings

  • Sport Sciences
  • 1117 Public Health and Health Services
  • 1116 Medical Physiology
  • 1106 Human Movement and Sports Sciences