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Comorbidity of age-related macular degeneration with Alzheimer's disease: A histopathologic case-control study.

Publication ,  Journal Article
Smilnak, GJ; Deans, JR; Doraiswamy, PM; Stinnett, S; Whitson, HE; Lad, EM
Published in: PLoS One
2019

INTRODUCTION: Previous studies evaluating the association between clinically diagnosed Alzheimer's disease (AD) and age-related macular degeneration (AMD) have generated conflicting results. This study is the first to assess whether AMD prevalence is higher in AD patients than non-AD controls by using histopathology to definitively diagnose AD. METHODS: This was a retrospective case-control study utilizing diagnostic information extracted from autopsy reports of patients age 75 and above, including 115 with a neuropathological diagnosis of AD and 57 age-matched normal controls. RESULTS: The rate of AMD was not significantly higher in AD cases (53.0%) than in controls (59.6%) (z = 0.820, p = 0.794). AMD severity as determined by Sarks score was similar between AD patients and controls (χ2 = 2.96, p = 0.706). There was also no significant association between Braak stage of AD severity and AMD (χ2 = 4.55, p = 0.602). DISCUSSION: No significant effect of AD diagnosis or pathologic severity on AMD comorbidity was found, suggesting that any shared mechanisms between AMD and AD may be nondeterministic.

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2019

Volume

14

Issue

9

Start / End Page

e0223199

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Retrospective Studies
  • North Carolina
  • Male
  • Macular Degeneration
  • Humans
  • Histocytochemistry
  • General Science & Technology
  • Female
  • Comorbidity
 

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Smilnak, G. J., Deans, J. R., Doraiswamy, P. M., Stinnett, S., Whitson, H. E., & Lad, E. M. (2019). Comorbidity of age-related macular degeneration with Alzheimer's disease: A histopathologic case-control study. PLoS One, 14(9), e0223199. https://doi.org/10.1371/journal.pone.0223199
Smilnak, Gordon J., John R. Deans, P Murali Doraiswamy, Sandra Stinnett, Heather E. Whitson, and Eleonora M. Lad. “Comorbidity of age-related macular degeneration with Alzheimer's disease: A histopathologic case-control study.PLoS One 14, no. 9 (2019): e0223199. https://doi.org/10.1371/journal.pone.0223199.
Smilnak GJ, Deans JR, Doraiswamy PM, Stinnett S, Whitson HE, Lad EM. Comorbidity of age-related macular degeneration with Alzheimer's disease: A histopathologic case-control study. PLoS One. 2019;14(9):e0223199.
Smilnak, Gordon J., et al. “Comorbidity of age-related macular degeneration with Alzheimer's disease: A histopathologic case-control study.PLoS One, vol. 14, no. 9, 2019, p. e0223199. Pubmed, doi:10.1371/journal.pone.0223199.
Smilnak GJ, Deans JR, Doraiswamy PM, Stinnett S, Whitson HE, Lad EM. Comorbidity of age-related macular degeneration with Alzheimer's disease: A histopathologic case-control study. PLoS One. 2019;14(9):e0223199.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2019

Volume

14

Issue

9

Start / End Page

e0223199

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Retrospective Studies
  • North Carolina
  • Male
  • Macular Degeneration
  • Humans
  • Histocytochemistry
  • General Science & Technology
  • Female
  • Comorbidity