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The potential of cerebrospinal fluid-based liquid biopsy approaches in CNS tumors.

Publication ,  Journal Article
Mattox, AK; Yan, H; Bettegowda, C
Published in: Neuro Oncol
December 17, 2019

Cerebrospinal fluid (CSF) may be the best hope for minimally invasive diagnosis and treatment monitoring of central nervous system (CNS) malignancies. Discovery/validation of cell-free nucleic acid and protein biomarkers has the potential to revolutionize CNS cancer care, paving the way for presurgical evaluation, earlier detection of recurrence, and the selection of targeted therapies. While detection of mutations, changes in RNA and miRNA expression, epigenetic alterations, and elevations of protein levels have been detected in the CSF of patients with CNS tumors, most of these biomarkers remain unvalidated. In this review, we focus on the molecular changes that have been identified in a variety of CNS tumors and profile the approaches used to detect these alterations in clinical samples. We further emphasize the importance of systemic collection of CSF and the establishment of standardized collection protocols that will lead to better cross-study biomarker validation and hopefully FDA-approved clinical markers.

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Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

December 17, 2019

Volume

21

Issue

12

Start / End Page

1509 / 1518

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Liquid Biopsy
  • Humans
  • Central Nervous System Neoplasms
  • Biomarkers, Tumor
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1109 Neurosciences
 

Citation

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Mattox, A. K., Yan, H., & Bettegowda, C. (2019). The potential of cerebrospinal fluid-based liquid biopsy approaches in CNS tumors. Neuro Oncol, 21(12), 1509–1518. https://doi.org/10.1093/neuonc/noz156
Mattox, Austin K., Hai Yan, and Chetan Bettegowda. “The potential of cerebrospinal fluid-based liquid biopsy approaches in CNS tumors.Neuro Oncol 21, no. 12 (December 17, 2019): 1509–18. https://doi.org/10.1093/neuonc/noz156.
Mattox AK, Yan H, Bettegowda C. The potential of cerebrospinal fluid-based liquid biopsy approaches in CNS tumors. Neuro Oncol. 2019 Dec 17;21(12):1509–18.
Mattox, Austin K., et al. “The potential of cerebrospinal fluid-based liquid biopsy approaches in CNS tumors.Neuro Oncol, vol. 21, no. 12, Dec. 2019, pp. 1509–18. Pubmed, doi:10.1093/neuonc/noz156.
Mattox AK, Yan H, Bettegowda C. The potential of cerebrospinal fluid-based liquid biopsy approaches in CNS tumors. Neuro Oncol. 2019 Dec 17;21(12):1509–1518.
Journal cover image

Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

December 17, 2019

Volume

21

Issue

12

Start / End Page

1509 / 1518

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Liquid Biopsy
  • Humans
  • Central Nervous System Neoplasms
  • Biomarkers, Tumor
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1109 Neurosciences