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Neurotransmitter Imbalance in the Brain and Alzheimer's Disease Pathology.

Publication ,  Journal Article
Snowden, SG; Ebshiana, AA; Hye, A; Pletnikova, O; O'Brien, R; Yang, A; Troncoso, J; Legido-Quigley, C; Thambisetty, M
Published in: J Alzheimers Dis
2019

BACKGROUND: Cholinesterase inhibitors represent three of the four treatments for Alzheimer's disease (AD), and target the pathological reduction of acetylcholine levels. Here we aimed to study the role of other neurotransmitter pathways in AD pathology. OBJECTIVE: This study aimed to determine associations between AD pathology at both symptomatic and asymptomatic stages of disease progression, and the metabolism of a range of non-cholinergic neurotransmitters. METHODS: Tissue samples were obtained from three groups, controls, AD, and 'asymptomatic AD' (ASYMAD), i.e., cognitively normal individuals that had significant AD neuropathology. Three brain areas were studied, the middle frontal gyrus (MFG), the inferior temporal gyrus (ITG), and the cerebellum. RESULTS: 12 of 15 metabolites involved in neurotransmitter metabolism were shown to be associated with AD pathology. Decreases in dopamine were most pronounced in the MFG with lower levels seen in the ASYMAD group compared to control (FC = 0.78, p = 2.9×10-2). In the ITG significant changes were seen in GABAergic and serotonin metabolism between control and AD patients; however, these changes were not seen between control and ASYMAD individuals. CONCLUSION: These results indicate that dopamine could be depleted in brains with AD pathology but intact cognition, while an imbalance of several neurotransmitters is evident in the brains of AD patients.

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Published In

J Alzheimers Dis

DOI

EISSN

1875-8908

Publication Date

2019

Volume

72

Issue

1

Start / End Page

35 / 43

Location

Netherlands

Related Subject Headings

  • Prospective Studies
  • Neurotransmitter Agents
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Female
  • Dopamine
  • Cohort Studies
  • Cholinesterase Inhibitors
 

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Snowden, S. G., Ebshiana, A. A., Hye, A., Pletnikova, O., O’Brien, R., Yang, A., … Thambisetty, M. (2019). Neurotransmitter Imbalance in the Brain and Alzheimer's Disease Pathology. J Alzheimers Dis, 72(1), 35–43. https://doi.org/10.3233/JAD-190577
Snowden, Stuart G., Amera A. Ebshiana, Abdul Hye, Olga Pletnikova, Richard O’Brien, An Yang, Juan Troncoso, Cristina Legido-Quigley, and Madhav Thambisetty. “Neurotransmitter Imbalance in the Brain and Alzheimer's Disease Pathology.J Alzheimers Dis 72, no. 1 (2019): 35–43. https://doi.org/10.3233/JAD-190577.
Snowden SG, Ebshiana AA, Hye A, Pletnikova O, O’Brien R, Yang A, et al. Neurotransmitter Imbalance in the Brain and Alzheimer's Disease Pathology. J Alzheimers Dis. 2019;72(1):35–43.
Snowden, Stuart G., et al. “Neurotransmitter Imbalance in the Brain and Alzheimer's Disease Pathology.J Alzheimers Dis, vol. 72, no. 1, 2019, pp. 35–43. Pubmed, doi:10.3233/JAD-190577.
Snowden SG, Ebshiana AA, Hye A, Pletnikova O, O’Brien R, Yang A, Troncoso J, Legido-Quigley C, Thambisetty M. Neurotransmitter Imbalance in the Brain and Alzheimer's Disease Pathology. J Alzheimers Dis. 2019;72(1):35–43.

Published In

J Alzheimers Dis

DOI

EISSN

1875-8908

Publication Date

2019

Volume

72

Issue

1

Start / End Page

35 / 43

Location

Netherlands

Related Subject Headings

  • Prospective Studies
  • Neurotransmitter Agents
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Female
  • Dopamine
  • Cohort Studies
  • Cholinesterase Inhibitors