Skip to main content
Journal cover image

Vertebral artery fusiform aneurysm geometry in predicting rupture risk.

Publication ,  Journal Article
Zhao, X; Gold, N; Fang, Y; Xu, S; Zhang, Y; Liu, J; Gupta, A; Huang, H
Published in: Royal Society open science
October 2018

Cerebral aneurysms affect a significant portion of the adult population worldwide. Despite significant progress, the development of robust techniques to evaluate the risk of aneurysm rupture remains a critical challenge. We hypothesize that vertebral artery fusiform aneurysm (VAFA) morphology may be predictive of rupture risk and can serve as a deciding factor in clinical management. To investigate the VAFA morphology, we use a combination of image analysis and machine learning techniques to study a geometric feature set computed from a depository of 37 (12 ruptured and 25 un-ruptured) aneurysm images. Of the 571 unique features we compute, we distinguish five features for use by our machine learning classification algorithm by an analysis of statistical significance. These machine learning methods achieve state-of-the-art classification performance (81.43 ± 13.08%) for the VAFA morphology, and identify five features (cross-sectional area change of aneurysm, maximum diameter of nearby distal vessel, solidity of aneurysm, maximum curvature of nearby distal vessel, and ratio of curvature between aneurysm and its nearby proximal vessel) as effective predictors of VAFA rupture risk. These results suggest that the geometric features of VAFA morphology may serve as useful non-invasive indicators for the prediction of aneurysm rupture risk in surgical settings.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Royal Society open science

DOI

EISSN

2054-5703

ISSN

2054-5703

Publication Date

October 2018

Volume

5

Issue

10

Start / End Page

180780
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhao, X., Gold, N., Fang, Y., Xu, S., Zhang, Y., Liu, J., … Huang, H. (2018). Vertebral artery fusiform aneurysm geometry in predicting rupture risk. Royal Society Open Science, 5(10), 180780. https://doi.org/10.1098/rsos.180780
Zhao, Xiukun, Nathan Gold, Yibin Fang, Shixin Xu, Yongxin Zhang, Jianmin Liu, Arvind Gupta, and Huaxiong Huang. “Vertebral artery fusiform aneurysm geometry in predicting rupture risk.Royal Society Open Science 5, no. 10 (October 2018): 180780. https://doi.org/10.1098/rsos.180780.
Zhao X, Gold N, Fang Y, Xu S, Zhang Y, Liu J, et al. Vertebral artery fusiform aneurysm geometry in predicting rupture risk. Royal Society open science. 2018 Oct;5(10):180780.
Zhao, Xiukun, et al. “Vertebral artery fusiform aneurysm geometry in predicting rupture risk.Royal Society Open Science, vol. 5, no. 10, Oct. 2018, p. 180780. Epmc, doi:10.1098/rsos.180780.
Zhao X, Gold N, Fang Y, Xu S, Zhang Y, Liu J, Gupta A, Huang H. Vertebral artery fusiform aneurysm geometry in predicting rupture risk. Royal Society open science. 2018 Oct;5(10):180780.
Journal cover image

Published In

Royal Society open science

DOI

EISSN

2054-5703

ISSN

2054-5703

Publication Date

October 2018

Volume

5

Issue

10

Start / End Page

180780