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Opioid and benzodiazepine use during therapeutic hypothermia in encephalopathic neonates.

Publication ,  Journal Article
Berube, MW; Lemmon, ME; Pizoli, CE; Bidegain, M; Tolia, VN; Cotten, CM; Greenberg, RG
Published in: J Perinatol
January 2020

OBJECTIVES: To evaluate the use of sedatives and analgesics during therapeutic hypothermia in encephalopathic neonates and assess associations between medication exposure and hospital outcomes. STUDY DESIGN: We identified neonates ≥35 weeks gestational age treated with therapeutic hypothermia at 125 neonatal intensive care units between 2007 and 2015. We compared characteristics and hospital outcomes between unexposed neonates and neonates exposed to opioids and/or benzodiazepines. RESULTS: Opioids were administered to 1 677/2 621 (64%) neonates, and exposure increased from 38% in 2008 to 68% in 2015. Sedation/analgesia varied widely between centers. Opioid-exposed neonates experienced greater durations of respiratory support and were more likely to receive inotropes and inhaled nitric oxide. Mortality during postnatal days 0-3 was lower among opioid-exposed neonates (31/625 [5%]) than unexposed neonates (64/714 [9%]). CONCLUSIONS: Sedation/analgesia during therapeutic hypothermia is prevalent but not uniform across centers. Prospective studies are needed to assess if exposure independently predicts intensity and duration of physiologic support.

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Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

January 2020

Volume

40

Issue

1

Start / End Page

79 / 88

Location

United States

Related Subject Headings

  • Respiration, Artificial
  • Pediatrics
  • Male
  • Infant, Newborn
  • Hypoxia-Ischemia, Brain
  • Hypothermia, Induced
  • Hypnotics and Sedatives
  • Humans
  • Hospital Mortality
  • Female
 

Citation

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Berube, M. W., Lemmon, M. E., Pizoli, C. E., Bidegain, M., Tolia, V. N., Cotten, C. M., & Greenberg, R. G. (2020). Opioid and benzodiazepine use during therapeutic hypothermia in encephalopathic neonates. J Perinatol, 40(1), 79–88. https://doi.org/10.1038/s41372-019-0533-4
Berube, Megan W., Monica E. Lemmon, Carolyn E. Pizoli, Margarita Bidegain, Veeral N. Tolia, C Michael Cotten, and Rachel G. Greenberg. “Opioid and benzodiazepine use during therapeutic hypothermia in encephalopathic neonates.J Perinatol 40, no. 1 (January 2020): 79–88. https://doi.org/10.1038/s41372-019-0533-4.
Berube MW, Lemmon ME, Pizoli CE, Bidegain M, Tolia VN, Cotten CM, et al. Opioid and benzodiazepine use during therapeutic hypothermia in encephalopathic neonates. J Perinatol. 2020 Jan;40(1):79–88.
Berube, Megan W., et al. “Opioid and benzodiazepine use during therapeutic hypothermia in encephalopathic neonates.J Perinatol, vol. 40, no. 1, Jan. 2020, pp. 79–88. Pubmed, doi:10.1038/s41372-019-0533-4.
Berube MW, Lemmon ME, Pizoli CE, Bidegain M, Tolia VN, Cotten CM, Greenberg RG. Opioid and benzodiazepine use during therapeutic hypothermia in encephalopathic neonates. J Perinatol. 2020 Jan;40(1):79–88.

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

January 2020

Volume

40

Issue

1

Start / End Page

79 / 88

Location

United States

Related Subject Headings

  • Respiration, Artificial
  • Pediatrics
  • Male
  • Infant, Newborn
  • Hypoxia-Ischemia, Brain
  • Hypothermia, Induced
  • Hypnotics and Sedatives
  • Humans
  • Hospital Mortality
  • Female