Skip to main content
Journal cover image

Short-term quality of life after myomectomy for uterine fibroids from the COMPARE-UF Fibroid Registry.

Publication ,  Journal Article
Laughlin-Tommaso, SK; Lu, D; Thomas, L; Diamond, MP; Wallace, K; Wegienka, G; Vines, AI; Anchan, RM; Wang, T; Maxwell, GL; Jacoby, V ...
Published in: Am J Obstet Gynecol
April 2020

BACKGROUND: Uterine fibroids may decrease quality of life in a significant proportion of affected women. Myomectomy offers a uterine-sparing treatment option for patients with uterine fibroids that can be performed abdominally, laparoscopically (with or without robotic assistance), and hysteroscopically. Quality of life information using validated measures for different myomectomy routes, especially hysteroscopic myomectomy, is limited. OBJECTIVE: To compare women's perception of their short-term health-related quality of life measures and reported time to return to usual activities and return to work for different routes of myomectomy. MATERIALS AND METHODS: Comparing Options for Management: Patient-centered Results for Uterine Fibroids (COMPARE-UF) is a prospective nationwide fibroid registry that enrolled premenopausal women seeking treatment for uterine fibroids at 8 clinical sites. For this analysis, we included women undergoing hysteroscopic, abdominal, or laparoscopic myomectomy who completed the postprocedure questionnaire scheduled between 6 and 12 weeks after surgery. Health-related quality of life outcomes, such as pain, anxiety, and return to usual activitie, were assessed for each route. The hysteroscopic myomectomy group had large differences in demographics, fibroid number, and uterine size compared to the other groups; thus, a direct comparison of quality of life measures was performed only for abdominal and laparoscopic approaches after propensity weighting. Propensity weighting was done using 24 variables that included demographics, quality of life baseline measures, and fibroid and uterine measurements. RESULTS: A total of 1206 women from 8 COMPARE-UF sites underwent myomectomy (338 hysteroscopic, 519 laparoscopic, and 349 abdominal). All women had substantial improvement in short-term health-related quality of life and symptom severity scores, which was not different among groups. Average symptom severity scores decreased about 30 points in each group. Return to usual activities averaged 0 days (interquartile range, 0-14 days) for hysteroscopic myomectomy, 21 days (interquartile range, 14-28 days) for laparoscopic myomectomy, and 28 days (interquartile range, 14-35 days) for abdominal myomectomy. After propensity adjustment, quality of life outcomes in the laparoscopic and abdominal myomectomy groups were similar except for more anxiety in the laparoscopic myomectomy group and slightly more pain in the abdominal myomectomy group. After propensity weighting, return to usual activities favored laparoscopic compared to abdominal procedures; median time was the same at 21 days, but the highest quartile of women in the abdominal group needed an additional week of recovery (interquartile range,14.0-28.0 for laparoscopic versus 14.0-35.0 for abdominal, P < .01). Time to return to work was also longer in the abdominal arm (median, 22 days; interquartile range, 14-40 days, versus median, 42; interquartile range, 27-56). CONCLUSION: Women who underwent myomectomy had substantial improvement in health-related quality of life, regardless of route of myomectomy. After propensity weighting, abdominal myomectomy was associated with a nearly 2-week longer time to return to work than laparoscopic myomectomy.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

April 2020

Volume

222

Issue

4

Start / End Page

345.e1 / 345.e22

Location

United States

Related Subject Headings

  • Uterine Neoplasms
  • Uterine Myomectomy
  • Time Factors
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Robotic Surgical Procedures
  • Return to Work
  • Registries
  • Quality of Life
  • Postoperative Period
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Laughlin-Tommaso, S. K., Lu, D., Thomas, L., Diamond, M. P., Wallace, K., Wegienka, G., … Myers, E. R. (2020). Short-term quality of life after myomectomy for uterine fibroids from the COMPARE-UF Fibroid Registry. Am J Obstet Gynecol, 222(4), 345.e1-345.e22. https://doi.org/10.1016/j.ajog.2019.09.052
Laughlin-Tommaso, Shannon K., Di Lu, Laine Thomas, Michael P. Diamond, Kedra Wallace, Ganesa Wegienka, Anissa I. Vines, et al. “Short-term quality of life after myomectomy for uterine fibroids from the COMPARE-UF Fibroid Registry.Am J Obstet Gynecol 222, no. 4 (April 2020): 345.e1-345.e22. https://doi.org/10.1016/j.ajog.2019.09.052.
Laughlin-Tommaso SK, Lu D, Thomas L, Diamond MP, Wallace K, Wegienka G, et al. Short-term quality of life after myomectomy for uterine fibroids from the COMPARE-UF Fibroid Registry. Am J Obstet Gynecol. 2020 Apr;222(4):345.e1-345.e22.
Laughlin-Tommaso, Shannon K., et al. “Short-term quality of life after myomectomy for uterine fibroids from the COMPARE-UF Fibroid Registry.Am J Obstet Gynecol, vol. 222, no. 4, Apr. 2020, pp. 345.e1-345.e22. Pubmed, doi:10.1016/j.ajog.2019.09.052.
Laughlin-Tommaso SK, Lu D, Thomas L, Diamond MP, Wallace K, Wegienka G, Vines AI, Anchan RM, Wang T, Maxwell GL, Jacoby V, Marsh EE, Spies JB, Nicholson WK, Stewart EA, Myers ER. Short-term quality of life after myomectomy for uterine fibroids from the COMPARE-UF Fibroid Registry. Am J Obstet Gynecol. 2020 Apr;222(4):345.e1-345.e22.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

April 2020

Volume

222

Issue

4

Start / End Page

345.e1 / 345.e22

Location

United States

Related Subject Headings

  • Uterine Neoplasms
  • Uterine Myomectomy
  • Time Factors
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Robotic Surgical Procedures
  • Return to Work
  • Registries
  • Quality of Life
  • Postoperative Period