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Candida albicans reprioritizes metal handling during fluconazole stress.

Publication ,  Journal Article
Hunsaker, EW; Franz, KJ
Published in: Metallomics : integrated biometal science
December 2019

Maintenance of metal homeostasis is critical to cell survival due to the multitude of cellular processes that depend on one or more metal cofactors. Here, we show that the opportunistic fungal pathogen Candida albicans extensively remodels its metal homeostasis networks to respond to treatment with the antifungal drug fluconazole. Disruption of the ergosterol biosynthetic pathway by fluconazole requires C. albicans adaptation, including increased Cu import and storage, increased retention of Fe, Mn, and Zn, altered utilization of Cu- and Mn-dependent enzymes, mobilization of Fe stores, and increased production of the heme prosthetic group utilized by the enzyme target of fluconazole. The findings offer a new perspective for thinking about fungal response to drug stress that pushes cells out of their metal homeostatic zones, leading them to enact metal-associated adaptation mechanisms to restore homeostasis to survive.

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Published In

Metallomics : integrated biometal science

DOI

EISSN

1756-591X

ISSN

1756-5901

Publication Date

December 2019

Volume

11

Issue

12

Start / End Page

2020 / 2032

Related Subject Headings

  • Microbial Sensitivity Tests
  • Metals
  • Homeostasis
  • Fluconazole
  • Ergosterol
  • Drug Resistance, Fungal
  • Candida albicans
  • Biosynthetic Pathways
  • Antifungal Agents
  • Analytical Chemistry
 

Citation

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Hunsaker, E. W., & Franz, K. J. (2019). Candida albicans reprioritizes metal handling during fluconazole stress. Metallomics : Integrated Biometal Science, 11(12), 2020–2032. https://doi.org/10.1039/c9mt00228f
Hunsaker, Elizabeth W., and Katherine J. Franz. “Candida albicans reprioritizes metal handling during fluconazole stress.Metallomics : Integrated Biometal Science 11, no. 12 (December 2019): 2020–32. https://doi.org/10.1039/c9mt00228f.
Hunsaker EW, Franz KJ. Candida albicans reprioritizes metal handling during fluconazole stress. Metallomics : integrated biometal science. 2019 Dec;11(12):2020–32.
Hunsaker, Elizabeth W., and Katherine J. Franz. “Candida albicans reprioritizes metal handling during fluconazole stress.Metallomics : Integrated Biometal Science, vol. 11, no. 12, Dec. 2019, pp. 2020–32. Epmc, doi:10.1039/c9mt00228f.
Hunsaker EW, Franz KJ. Candida albicans reprioritizes metal handling during fluconazole stress. Metallomics : integrated biometal science. 2019 Dec;11(12):2020–2032.
Journal cover image

Published In

Metallomics : integrated biometal science

DOI

EISSN

1756-591X

ISSN

1756-5901

Publication Date

December 2019

Volume

11

Issue

12

Start / End Page

2020 / 2032

Related Subject Headings

  • Microbial Sensitivity Tests
  • Metals
  • Homeostasis
  • Fluconazole
  • Ergosterol
  • Drug Resistance, Fungal
  • Candida albicans
  • Biosynthetic Pathways
  • Antifungal Agents
  • Analytical Chemistry