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The U-shaped association between body mass index and gastric cancer risk in the Helicobacter pylori Biomarker Cohort Consortium: A nested case-control study from eight East Asian cohort studies.

Publication ,  Journal Article
Jang, J; Wang, T; Cai, H; Ye, F; Murphy, G; Shimazu, T; Taylor, PR; Qiao, Y-L; Yoo, K-Y; Jee, SH; Kim, J; Chen, S-C; Abnet, CC; Tsugane, S ...
Published in: Int J Cancer
August 1, 2020

The association between body mass index (BMI) and noncardia gastric cancer (NCGC) risk remains controversial. The purpose of our study was to examine the association of BMI with NCGC risk with consideration of Helicobacter pylori (HP) biomarkers. This international nested case-control study, composed of 1,591 incident NCGC cases and 1,953 matched controls, was established from eight cohorts in China, Japan and Korea, where the majority of NCGCs are diagnosed worldwide. HP antibody biomarkers were measured in blood collected at cohort enrollment by multiplex serology. The NCGC risk according to baseline BMI was estimated using logistic regression to produce odds ratios (ORs) and 95% confidence intervals (CIs). We found a U-shaped association between BMI category and NCGC risk. Compared to those with reference BMI (22.6-25.0 kg/m2 ), those with lower and higher BMI had an increased NCGC risk (BMI <18.5 kg/m2 , OR = 1.56, 95% CI = 1.04-2.34; BMI >27.5 kg/m2 , OR = 1.48, 95% CI = 1.15-1.91; adjusted for age, sex and smoking). The U-shaped association was persistent among subjects with HP infection and high-risk biomarkers (HP+ CagA+: BMI <18.5 kg/m2 , OR = 1.60, 95% CI = 1.00-2.55; BMI >27.5 kg/m2 , OR = 1.59, 95% CI = 1.21-2.11; and Omp+ HP0305+: BMI <18.5 kg/m2 , OR = 1.88, 95% CI = 1.04-3.42; BMI >27.5 kg/m2 , OR = 1.70, 95% CI = 1.20-2.42, respectively). Our study provides evidence of significantly increased NCGC risk among individuals with low or high BMI, including in subjects with high-risk HP biomarkers (HP+ CagA+, Omp+ HP0305+) in the high-risk area of East Asia.

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Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

August 1, 2020

Volume

147

Issue

3

Start / End Page

777 / 784

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Risk Factors
  • Republic of Korea
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Logistic Models
  • Japan
  • Humans
 

Citation

APA
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ICMJE
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Jang, J., Wang, T., Cai, H., Ye, F., Murphy, G., Shimazu, T., … Epplein, M. (2020). The U-shaped association between body mass index and gastric cancer risk in the Helicobacter pylori Biomarker Cohort Consortium: A nested case-control study from eight East Asian cohort studies. Int J Cancer, 147(3), 777–784. https://doi.org/10.1002/ijc.32790
Jang, Jieun, Tianyi Wang, Hui Cai, Fei Ye, Gwen Murphy, Taichi Shimazu, Philip R. Taylor, et al. “The U-shaped association between body mass index and gastric cancer risk in the Helicobacter pylori Biomarker Cohort Consortium: A nested case-control study from eight East Asian cohort studies.Int J Cancer 147, no. 3 (August 1, 2020): 777–84. https://doi.org/10.1002/ijc.32790.
Jang J, Wang T, Cai H, Ye F, Murphy G, Shimazu T, Taylor PR, Qiao Y-L, Yoo K-Y, Jee SH, Kim J, Chen S-C, Abnet CC, Tsugane S, Zheng W, Shu X-O, Pawlita M, Park SK, Epplein M. The U-shaped association between body mass index and gastric cancer risk in the Helicobacter pylori Biomarker Cohort Consortium: A nested case-control study from eight East Asian cohort studies. Int J Cancer. 2020 Aug 1;147(3):777–784.
Journal cover image

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

August 1, 2020

Volume

147

Issue

3

Start / End Page

777 / 784

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Risk Factors
  • Republic of Korea
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Logistic Models
  • Japan
  • Humans