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Heterogeneous Outcomes of Heart Failure with Better Ejection Fraction.

Publication ,  Journal Article
Van Kirk, J; Fudim, M; Green, CL; Karra, R
Published in: J Cardiovasc Transl Res
April 2020

We evaluated the heterogeneity of outcomes among heart failure patients with ventricular recovery. The BEST trial studied patients with left ventricular ejection fraction (LVEF) ≤ 35%. Serial LVEF assessment was performed at baseline, 3 months, and 12 months. Heart failure with better ejection fraction (HFbEF) was defined as an LVEF > 40% at any point. Of the patients who survived to 1 year, 399 (21.3%) had HFbEF. Among subjects with HFbEF, 173 (43.4%) had "extended" recovery, 161 (40.4%) had "late" recovery, and 65 (16.3%) patients had "transient" recovery. Subjects with HFbEF had an improved event-free survival from death or first HF hospitalization compared to subjects without recovery (HR 0.50, 95% CI, 0.39-0.64, p < 0.001). Compared to "transient" recovery, "late" and "extended" recovery were associated with an improved event-free survival from all-cause death and HF hospitalization (HR 0.55, 95% CI, 0.34-0.90, p = 0.016). Our study shows patients with HFbEF to be a heterogeneous population with differing prognoses.

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Published In

J Cardiovasc Transl Res

DOI

EISSN

1937-5395

Publication Date

April 2020

Volume

13

Issue

2

Start / End Page

142 / 150

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Time Factors
  • Stroke Volume
  • Risk Factors
  • Recovery of Function
  • Randomized Controlled Trials as Topic
  • Progression-Free Survival
  • Multicenter Studies as Topic
  • Middle Aged
  • Male
 

Citation

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Van Kirk, J., Fudim, M., Green, C. L., & Karra, R. (2020). Heterogeneous Outcomes of Heart Failure with Better Ejection Fraction. J Cardiovasc Transl Res, 13(2), 142–150. https://doi.org/10.1007/s12265-019-09919-9
Van Kirk, Jenny, Marat Fudim, Cynthia L. Green, and Ravi Karra. “Heterogeneous Outcomes of Heart Failure with Better Ejection Fraction.J Cardiovasc Transl Res 13, no. 2 (April 2020): 142–50. https://doi.org/10.1007/s12265-019-09919-9.
Van Kirk J, Fudim M, Green CL, Karra R. Heterogeneous Outcomes of Heart Failure with Better Ejection Fraction. J Cardiovasc Transl Res. 2020 Apr;13(2):142–50.
Van Kirk, Jenny, et al. “Heterogeneous Outcomes of Heart Failure with Better Ejection Fraction.J Cardiovasc Transl Res, vol. 13, no. 2, Apr. 2020, pp. 142–50. Pubmed, doi:10.1007/s12265-019-09919-9.
Van Kirk J, Fudim M, Green CL, Karra R. Heterogeneous Outcomes of Heart Failure with Better Ejection Fraction. J Cardiovasc Transl Res. 2020 Apr;13(2):142–150.
Journal cover image

Published In

J Cardiovasc Transl Res

DOI

EISSN

1937-5395

Publication Date

April 2020

Volume

13

Issue

2

Start / End Page

142 / 150

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Time Factors
  • Stroke Volume
  • Risk Factors
  • Recovery of Function
  • Randomized Controlled Trials as Topic
  • Progression-Free Survival
  • Multicenter Studies as Topic
  • Middle Aged
  • Male