Retrospective Diagnosis of Ataxia-Telangiectasia in an Adolescent Patient With a Remote History of T-Cell Leukemia.
Publication
, Journal Article
Sze, S-GK; Lederman, HM; Crawford, TO; Wangler, MF; Lewis, AM; Kastan, MB; Dibra, HK; Taylor, AMR; Wechsler, DS
Published in: J Pediatr Hematol Oncol
January 2021
Ataxia-telangiectasia (A-T) is a rare autosomal recessive disorder characterized by progressive cerebellar degeneration that is typically diagnosed in early childhood. A-T is associated with a predisposition to malignancies, particularly lymphoid tumors in childhood and early adulthood. An adolescent girl with minimal neurologic symptoms was diagnosed with A-T 8 years after completing therapy for T-cell acute lymphoblastic leukemia, following a diagnosis of ATM-mutated breast cancer in her mother. We highlight the importance of recognizing ATM mutations in T-cell acute lymphoblastic leukemia, appreciating the phenotypic heterogeneity of A-T, and defining optimal cancer screening in A-T patients.
Duke Scholars
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Published In
J Pediatr Hematol Oncol
DOI
EISSN
1536-3678
Publication Date
January 2021
Volume
43
Issue
1
Start / End Page
e138 / e140
Location
United States
Related Subject Headings
- Retrospective Studies
- Prognosis
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
- Oncology & Carcinogenesis
- Mutation
- Humans
- Female
- Combined Modality Therapy
- Ataxia Telangiectasia Mutated Proteins
- Ataxia Telangiectasia
Citation
APA
Chicago
ICMJE
MLA
NLM
Sze, S.-G., Lederman, H. M., Crawford, T. O., Wangler, M. F., Lewis, A. M., Kastan, M. B., … Wechsler, D. S. (2021). Retrospective Diagnosis of Ataxia-Telangiectasia in an Adolescent Patient With a Remote History of T-Cell Leukemia. J Pediatr Hematol Oncol, 43(1), e138–e140. https://doi.org/10.1097/MPH.0000000000001672
Sze, Sei-Gyung K., Howard M. Lederman, Thomas O. Crawford, Michael F. Wangler, Andrea M. Lewis, Michael B. Kastan, Harpreet K. Dibra, Alexander M. R. Taylor, and Daniel S. Wechsler. “Retrospective Diagnosis of Ataxia-Telangiectasia in an Adolescent Patient With a Remote History of T-Cell Leukemia.” J Pediatr Hematol Oncol 43, no. 1 (January 2021): e138–40. https://doi.org/10.1097/MPH.0000000000001672.
Sze S-GK, Lederman HM, Crawford TO, Wangler MF, Lewis AM, Kastan MB, et al. Retrospective Diagnosis of Ataxia-Telangiectasia in an Adolescent Patient With a Remote History of T-Cell Leukemia. J Pediatr Hematol Oncol. 2021 Jan;43(1):e138–40.
Sze, Sei-Gyung K., et al. “Retrospective Diagnosis of Ataxia-Telangiectasia in an Adolescent Patient With a Remote History of T-Cell Leukemia.” J Pediatr Hematol Oncol, vol. 43, no. 1, Jan. 2021, pp. e138–40. Pubmed, doi:10.1097/MPH.0000000000001672.
Sze S-GK, Lederman HM, Crawford TO, Wangler MF, Lewis AM, Kastan MB, Dibra HK, Taylor AMR, Wechsler DS. Retrospective Diagnosis of Ataxia-Telangiectasia in an Adolescent Patient With a Remote History of T-Cell Leukemia. J Pediatr Hematol Oncol. 2021 Jan;43(1):e138–e140.
Published In
J Pediatr Hematol Oncol
DOI
EISSN
1536-3678
Publication Date
January 2021
Volume
43
Issue
1
Start / End Page
e138 / e140
Location
United States
Related Subject Headings
- Retrospective Studies
- Prognosis
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
- Oncology & Carcinogenesis
- Mutation
- Humans
- Female
- Combined Modality Therapy
- Ataxia Telangiectasia Mutated Proteins
- Ataxia Telangiectasia