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Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration.

Publication ,  Journal Article
Gancz, D; Raftrey, BC; Perlmoter, G; Marín-Juez, R; Semo, J; Matsuoka, RL; Karra, R; Raviv, H; Moshe, N; Addadi, Y; Golani, O; Poss, KD ...
Published in: Elife
November 8, 2019

In recent years, there has been increasing interest in the role of lymphatics in organ repair and regeneration, due to their importance in immune surveillance and fluid homeostasis. Experimental approaches aimed at boosting lymphangiogenesis following myocardial infarction in mice, were shown to promote healing of the heart. Yet, the mechanisms governing cardiac lymphatic growth remain unclear. Here, we identify two distinct lymphatic populations in the hearts of zebrafish and mouse, one that forms through sprouting lymphangiogenesis, and the other by coalescence of isolated lymphatic cells. By tracing the development of each subset, we reveal diverse cellular origins and differential response to signaling cues. Finally, we show that lymphatic vessels are required for cardiac regeneration in zebrafish as mutants lacking lymphatics display severely impaired regeneration capabilities. Overall, our results provide novel insight into the mechanisms underlying lymphatic formation during development and regeneration, opening new avenues for interventions targeting specific lymphatic populations.

Duke Scholars

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Published In

Elife

DOI

EISSN

2050-084X

Publication Date

November 8, 2019

Volume

8

Location

England

Related Subject Headings

  • Zebrafish
  • Signal Transduction
  • Regeneration
  • Myocardium
  • Myocardial Infarction
  • Mutation
  • Mice, Transgenic
  • Mice, Knockout
  • Lymphatic Vessels
  • Lymphatic System
 

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Gancz, D., Raftrey, B. C., Perlmoter, G., Marín-Juez, R., Semo, J., Matsuoka, R. L., … Yaniv, K. (2019). Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration. Elife, 8. https://doi.org/10.7554/eLife.44153
Gancz, Dana, Brian C. Raftrey, Gal Perlmoter, Rubén Marín-Juez, Jonathan Semo, Ryota L. Matsuoka, Ravi Karra, et al. “Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration.Elife 8 (November 8, 2019). https://doi.org/10.7554/eLife.44153.
Gancz D, Raftrey BC, Perlmoter G, Marín-Juez R, Semo J, Matsuoka RL, et al. Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration. Elife. 2019 Nov 8;8.
Gancz, Dana, et al. “Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration.Elife, vol. 8, Nov. 2019. Pubmed, doi:10.7554/eLife.44153.
Gancz D, Raftrey BC, Perlmoter G, Marín-Juez R, Semo J, Matsuoka RL, Karra R, Raviv H, Moshe N, Addadi Y, Golani O, Poss KD, Red-Horse K, Stainier DY, Yaniv K. Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration. Elife. 2019 Nov 8;8.

Published In

Elife

DOI

EISSN

2050-084X

Publication Date

November 8, 2019

Volume

8

Location

England

Related Subject Headings

  • Zebrafish
  • Signal Transduction
  • Regeneration
  • Myocardium
  • Myocardial Infarction
  • Mutation
  • Mice, Transgenic
  • Mice, Knockout
  • Lymphatic Vessels
  • Lymphatic System