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Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models.

Publication ,  Journal Article
Deerhake, ME; Biswas, DD; Barclay, WE; Shinohara, ML
Published in: Front Immunol
2019

Pattern recognition receptors (PRRs) coordinate the innate immune response and have a significant role in the development of multiple sclerosis (MS). Accumulating evidence has identified both pathogenic and protective functions of PRR signaling in MS and its animal model, experimental autoimmune encephalomyelitis (EAE). Additionally, evidence for PRR signaling in non-immune cells and PRR responses to host-derived endogenous ligands has also revealed new pathways controlling the development of CNS autoimmunity. Many PRRs remain uncharacterized in MS and EAE, and understanding the distinct triggers and functions of PRR signaling in CNS autoimmunity requires further investigation. In this brief review, we discuss the diverse pathogenic and protective functions of PRRs in MS and EAE, and highlight major avenues for future research.

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Published In

Front Immunol

DOI

EISSN

1664-3224

Publication Date

2019

Volume

10

Start / End Page

2644

Location

Switzerland

Related Subject Headings

  • Receptors, Pattern Recognition
  • Multiple Sclerosis
  • Immunity, Innate
  • Humans
  • Encephalomyelitis, Autoimmune, Experimental
  • Autoimmunity
  • Animals
  • 3204 Immunology
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
 

Citation

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Deerhake, M. E., Biswas, D. D., Barclay, W. E., & Shinohara, M. L. (2019). Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models. Front Immunol, 10, 2644. https://doi.org/10.3389/fimmu.2019.02644
Deerhake, M Elizabeth, Debolina D. Biswas, William E. Barclay, and Mari L. Shinohara. “Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models.Front Immunol 10 (2019): 2644. https://doi.org/10.3389/fimmu.2019.02644.
Deerhake ME, Biswas DD, Barclay WE, Shinohara ML. Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models. Front Immunol. 2019;10:2644.
Deerhake, M. Elizabeth, et al. “Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models.Front Immunol, vol. 10, 2019, p. 2644. Pubmed, doi:10.3389/fimmu.2019.02644.
Deerhake ME, Biswas DD, Barclay WE, Shinohara ML. Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models. Front Immunol. 2019;10:2644.

Published In

Front Immunol

DOI

EISSN

1664-3224

Publication Date

2019

Volume

10

Start / End Page

2644

Location

Switzerland

Related Subject Headings

  • Receptors, Pattern Recognition
  • Multiple Sclerosis
  • Immunity, Innate
  • Humans
  • Encephalomyelitis, Autoimmune, Experimental
  • Autoimmunity
  • Animals
  • 3204 Immunology
  • 3105 Genetics
  • 3101 Biochemistry and cell biology