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Microglia and sexual differentiation of the developing brain: A focus on ontogeny and intrinsic factors.

Publication ,  Journal Article
Bordt, EA; Ceasrine, AM; Bilbo, SD
Published in: Glia
June 2020

Sexual differentiation of the brain during early development likely underlies the strong sex biases prevalent in many neurological conditions. Mounting evidence indicates that microglia, the innate immune cells of the central nervous system, are intricately involved in these sex-specific processes of differentiation. In this review, we synthesize literature demonstrating sex differences in microglial number, morphology, transcriptional state, and functionality throughout spatiotemporal development as well as highlight current literature regarding ontogeny of microglia. Along with vanRyzin et al. in this issue, we explore the idea that differences in microglia imparted by chromosomal or ontogeny-related programming can influence microglial-driven sexual differentiation of the brain, as well as the idea that extrinsic differences in the male and female brain microenvironment may in turn impart sex differences in microglia.

Duke Scholars

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Published In

Glia

DOI

EISSN

1098-1136

ISSN

0894-1491

Publication Date

June 2020

Volume

68

Issue

6

Start / End Page

1085 / 1099

Related Subject Headings

  • Sex Differentiation
  • Sex Characteristics
  • Neurons
  • Neurology & Neurosurgery
  • Nervous System Diseases
  • Microglia
  • Male
  • Humans
  • Brain
  • Animals
 

Citation

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Bordt, E. A., Ceasrine, A. M., & Bilbo, S. D. (2020). Microglia and sexual differentiation of the developing brain: A focus on ontogeny and intrinsic factors. Glia, 68(6), 1085–1099. https://doi.org/10.1002/glia.23753
Bordt, Evan A., Alexis M. Ceasrine, and Staci D. Bilbo. “Microglia and sexual differentiation of the developing brain: A focus on ontogeny and intrinsic factors.Glia 68, no. 6 (June 2020): 1085–99. https://doi.org/10.1002/glia.23753.
Bordt, Evan A., et al. “Microglia and sexual differentiation of the developing brain: A focus on ontogeny and intrinsic factors.Glia, vol. 68, no. 6, June 2020, pp. 1085–99. Epmc, doi:10.1002/glia.23753.
Journal cover image

Published In

Glia

DOI

EISSN

1098-1136

ISSN

0894-1491

Publication Date

June 2020

Volume

68

Issue

6

Start / End Page

1085 / 1099

Related Subject Headings

  • Sex Differentiation
  • Sex Characteristics
  • Neurons
  • Neurology & Neurosurgery
  • Nervous System Diseases
  • Microglia
  • Male
  • Humans
  • Brain
  • Animals