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Low Testosterone Is Associated With Nonalcoholic Steatohepatitis and Fibrosis Severity in Men.

Publication ,  Journal Article
Sarkar, M; Yates, K; Suzuki, A; Lavine, J; Gill, R; Ziegler, T; Terrault, N; Dhindsa, S
Published in: Clin Gastroenterol Hepatol
February 2021

With rising prevalence of obesity and diabetes, nonalcoholic fatty liver disease (NAFLD) is now a leading cause of chronic liver disease. One-third of obese or diabetic men have subnormal free and bioavailable testosterone concentrations.1 Several studies have further shown low testosterone to be associated with imaging-confirmed NAFLD in men,2 although it is unknown whether low testosterone confers increased risk of more clinically relevant manifestations of NAFLD, including nonalcoholic steatohepatitis (NASH) and NASH fibrosis. We therefore aimed to evaluate the association of testosterone with histologic features of NAFLD among a representative cohort of men from the multicenter NASH Clinical Research Network (NASH CRN).

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Published In

Clin Gastroenterol Hepatol

DOI

EISSN

1542-7714

Publication Date

February 2021

Volume

19

Issue

2

Start / End Page

400 / 402.e2

Location

United States

Related Subject Headings

  • Testosterone
  • Obesity
  • Non-alcoholic Fatty Liver Disease
  • Male
  • Liver
  • Humans
  • Gastroenterology & Hepatology
  • Fibrosis
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Sarkar, M., Yates, K., Suzuki, A., Lavine, J., Gill, R., Ziegler, T., … Dhindsa, S. (2021). Low Testosterone Is Associated With Nonalcoholic Steatohepatitis and Fibrosis Severity in Men. Clin Gastroenterol Hepatol, 19(2), 400-402.e2. https://doi.org/10.1016/j.cgh.2019.11.053
Sarkar, Monika, Katherine Yates, Ayako Suzuki, Joel Lavine, Ryan Gill, Toni Ziegler, Norah Terrault, and Sandeep Dhindsa. “Low Testosterone Is Associated With Nonalcoholic Steatohepatitis and Fibrosis Severity in Men.Clin Gastroenterol Hepatol 19, no. 2 (February 2021): 400-402.e2. https://doi.org/10.1016/j.cgh.2019.11.053.
Sarkar M, Yates K, Suzuki A, Lavine J, Gill R, Ziegler T, et al. Low Testosterone Is Associated With Nonalcoholic Steatohepatitis and Fibrosis Severity in Men. Clin Gastroenterol Hepatol. 2021 Feb;19(2):400-402.e2.
Sarkar, Monika, et al. “Low Testosterone Is Associated With Nonalcoholic Steatohepatitis and Fibrosis Severity in Men.Clin Gastroenterol Hepatol, vol. 19, no. 2, Feb. 2021, pp. 400-402.e2. Pubmed, doi:10.1016/j.cgh.2019.11.053.
Sarkar M, Yates K, Suzuki A, Lavine J, Gill R, Ziegler T, Terrault N, Dhindsa S. Low Testosterone Is Associated With Nonalcoholic Steatohepatitis and Fibrosis Severity in Men. Clin Gastroenterol Hepatol. 2021 Feb;19(2):400-402.e2.
Journal cover image

Published In

Clin Gastroenterol Hepatol

DOI

EISSN

1542-7714

Publication Date

February 2021

Volume

19

Issue

2

Start / End Page

400 / 402.e2

Location

United States

Related Subject Headings

  • Testosterone
  • Obesity
  • Non-alcoholic Fatty Liver Disease
  • Male
  • Liver
  • Humans
  • Gastroenterology & Hepatology
  • Fibrosis
  • 3202 Clinical sciences
  • 1103 Clinical Sciences