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Differential Control of iNKT Cell Effector Lineage Differentiation by the Forkhead Box Protein O1 (Foxo1) Transcription Factor.

Publication ,  Journal Article
Tao, H; Li, L; Gao, Y; Wang, Z; Zhong, X-P
Published in: Front Immunol
2019

The invariant NKT (iNKT) cells recognize glycolipid antigens presented by the non-classical MHC like molecule CD1d. They represent an innate T-cell lineage with the ability to rapidly produce a variety of cytokines in response to agonist stimulation to bridge innate and adaptive immunity. In thymus, most iNKT cells complete their maturation and differentiate to multiple effector lineages such as iNKT-1, iNKT-2, and iNKT-17 cells that possess the capability to produce IFNγ, IL-4, and IL-17A, respectively, and play distinct roles in immune responses and diseases. Mechanisms that control iNKT lineage fate decisions are still not well understood. Evidence has revealed critical roles of Foxo1 of the forkhead box O1 subfamily of transcription factors in the immune system. However, its role in iNKT cells has been unknown. In this report, we demonstrate that deletion of Foxo1 causes severe decreases of iNKT cell total numbers due to impairment of late but not early iNKT cell development. Deficiency of Foxo1 results in decreases of iNKT-1 but increases of iNKT-17 cells. Our data reveal that Foxo1 controls iNKT effector lineage fate decision by promoting iNKT-1 but suppressing iNKT-17 lineages.

Duke Scholars

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Published In

Front Immunol

DOI

EISSN

1664-3224

Publication Date

2019

Volume

10

Start / End Page

2710

Location

Switzerland

Related Subject Headings

  • T-Lymphocyte Subsets
  • Natural Killer T-Cells
  • Mice, Transgenic
  • Mice
  • Gene Knockout Techniques
  • Forkhead Box Protein O1
  • Cell Lineage
  • Cell Differentiation
  • Biomarkers
  • Animals
 

Citation

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Tao, H., Li, L., Gao, Y., Wang, Z., & Zhong, X.-P. (2019). Differential Control of iNKT Cell Effector Lineage Differentiation by the Forkhead Box Protein O1 (Foxo1) Transcription Factor. Front Immunol, 10, 2710. https://doi.org/10.3389/fimmu.2019.02710
Tao, Huishan, Lei Li, Ying Gao, Zehua Wang, and Xiao-Ping Zhong. “Differential Control of iNKT Cell Effector Lineage Differentiation by the Forkhead Box Protein O1 (Foxo1) Transcription Factor.Front Immunol 10 (2019): 2710. https://doi.org/10.3389/fimmu.2019.02710.
Tao, Huishan, et al. “Differential Control of iNKT Cell Effector Lineage Differentiation by the Forkhead Box Protein O1 (Foxo1) Transcription Factor.Front Immunol, vol. 10, 2019, p. 2710. Pubmed, doi:10.3389/fimmu.2019.02710.

Published In

Front Immunol

DOI

EISSN

1664-3224

Publication Date

2019

Volume

10

Start / End Page

2710

Location

Switzerland

Related Subject Headings

  • T-Lymphocyte Subsets
  • Natural Killer T-Cells
  • Mice, Transgenic
  • Mice
  • Gene Knockout Techniques
  • Forkhead Box Protein O1
  • Cell Lineage
  • Cell Differentiation
  • Biomarkers
  • Animals