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Alu insertion polymorphisms shared by Papio baboons and Theropithecus gelada reveal an intertwined common ancestry.

Publication ,  Journal Article
Walker, JA; Jordan, VE; Storer, JM; Steely, CJ; Gonzalez-Quiroga, P; Beckstrom, TO; Rewerts, LC; St Romain, CP; Rockwell, CE; Rogers, J ...
Published in: Mobile DNA
January 2019

Baboons (genus Papio) and geladas (Theropithecus gelada) are now generally recognized as close phylogenetic relatives, though morphologically quite distinct and generally classified in separate genera. Primate specific Alu retrotransposons are well-established genomic markers for the study of phylogenetic and population genetic relationships. We previously reported a computational reconstruction of Papio phylogeny using large-scale whole genome sequence (WGS) analysis of Alu insertion polymorphisms. Recently, high coverage WGS was generated for Theropithecus gelada. The objective of this study was to apply the high-throughput "poly-Detect" method to computationally determine the number of Alu insertion polymorphisms shared by T. gelada and Papio, and vice versa, by each individual Papio species and T. gelada. Secondly, we performed locus-specific polymerase chain reaction (PCR) assays on a diverse DNA panel to complement the computational data.We identified 27,700 Alu insertions from T. gelada WGS that were also present among six Papio species, with nearly half (12,956) remaining unfixed among 12 Papio individuals. Similarly, each of the six Papio species had species-indicative Alu insertions that were also present in T. gelada. In general, P. kindae shared more insertion polymorphisms with T. gelada than did any of the other five Papio species. PCR-based genotype data provided additional support for the computational findings.Our discovery that several thousand Alu insertion polymorphisms are shared by T. gelada and Papio baboons suggests a much more permeable reproductive barrier between the two genera then previously suspected. Their intertwined evolution likely involves a long history of admixture, gene flow and incomplete lineage sorting.

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Published In

Mobile DNA

DOI

EISSN

1759-8753

ISSN

1759-8753

Publication Date

January 2019

Volume

10

Start / End Page

46

Related Subject Headings

  • 3105 Genetics
  • 0604 Genetics
 

Citation

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ICMJE
MLA
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Walker, J. A., Jordan, V. E., Storer, J. M., Steely, C. J., Gonzalez-Quiroga, P., Beckstrom, T. O., … Batzer, M. A. (2019). Alu insertion polymorphisms shared by Papio baboons and Theropithecus gelada reveal an intertwined common ancestry. Mobile DNA, 10, 46. https://doi.org/10.1186/s13100-019-0187-y
Walker, Jerilyn A., Vallmer E. Jordan, Jessica M. Storer, Cody J. Steely, Paulina Gonzalez-Quiroga, Thomas O. Beckstrom, Lydia C. Rewerts, et al. “Alu insertion polymorphisms shared by Papio baboons and Theropithecus gelada reveal an intertwined common ancestry.Mobile DNA 10 (January 2019): 46. https://doi.org/10.1186/s13100-019-0187-y.
Walker JA, Jordan VE, Storer JM, Steely CJ, Gonzalez-Quiroga P, Beckstrom TO, et al. Alu insertion polymorphisms shared by Papio baboons and Theropithecus gelada reveal an intertwined common ancestry. Mobile DNA. 2019 Jan;10:46.
Walker, Jerilyn A., et al. “Alu insertion polymorphisms shared by Papio baboons and Theropithecus gelada reveal an intertwined common ancestry.Mobile DNA, vol. 10, Jan. 2019, p. 46. Epmc, doi:10.1186/s13100-019-0187-y.
Walker JA, Jordan VE, Storer JM, Steely CJ, Gonzalez-Quiroga P, Beckstrom TO, Rewerts LC, St Romain CP, Rockwell CE, Rogers J, Jolly CJ, Konkel MK, Baboon Genome Analysis Consortium, Batzer MA. Alu insertion polymorphisms shared by Papio baboons and Theropithecus gelada reveal an intertwined common ancestry. Mobile DNA. 2019 Jan;10:46.
Journal cover image

Published In

Mobile DNA

DOI

EISSN

1759-8753

ISSN

1759-8753

Publication Date

January 2019

Volume

10

Start / End Page

46

Related Subject Headings

  • 3105 Genetics
  • 0604 Genetics