Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis.
Publication
, Journal Article
Yi, JS; Russo, MA; Raja, S; Massey, JM; Juel, VC; Shin, J; Hobson-Webb, LD; Gable, K; Guptill, JT
Published in: Exp Neurol
March 2020
IL-17 producing CD4 T cells (Th17) cells increase significantly with disease severity in myasthenia gravis (MG) patients. To suppress the generation of Th17 cells, we examined the effect of inhibiting retinoic acid receptor-related-orphan-receptor-C (RORγ), a Th17-specific transcription factor critical for differentiation. RORγ inhibition profoundly reduced Th17 cell frequencies, including IFN-γ and IL-17 co-producing pathogenic Th17 cells. Other T helper subsets were not affected. In parallel, CD8 T cell subsets producing IL-17 and IL-17/IFN-γ were increased in MG patients and inhibited by the RORγ inhibitor. These findings provide rationale for exploration of targeted Th17 therapies, including ROR-γ inhibitors, to treat MG patients.
Duke Scholars
Published In
Exp Neurol
DOI
EISSN
1090-2430
Publication Date
March 2020
Volume
325
Start / End Page
113146
Location
United States
Related Subject Headings
- Th17 Cells
- Receptors, Cholinergic
- Nuclear Receptor Subfamily 1, Group F, Member 3
- Neurology & Neurosurgery
- Myasthenia Gravis
- Middle Aged
- Male
- Interleukin-17
- Immunologic Factors
- Humans
Citation
APA
Chicago
ICMJE
MLA
NLM
Yi, J. S., Russo, M. A., Raja, S., Massey, J. M., Juel, V. C., Shin, J., … Guptill, J. T. (2020). Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis. Exp Neurol, 325, 113146. https://doi.org/10.1016/j.expneurol.2019.113146
Yi, John S., Melissa A. Russo, Shruti Raja, Janice M. Massey, Vern C. Juel, Jay Shin, Lisa D. Hobson-Webb, Karissa Gable, and Jeffrey T. Guptill. “Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis.” Exp Neurol 325 (March 2020): 113146. https://doi.org/10.1016/j.expneurol.2019.113146.
Yi JS, Russo MA, Raja S, Massey JM, Juel VC, Shin J, et al. Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis. Exp Neurol. 2020 Mar;325:113146.
Yi, John S., et al. “Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis.” Exp Neurol, vol. 325, Mar. 2020, p. 113146. Pubmed, doi:10.1016/j.expneurol.2019.113146.
Yi JS, Russo MA, Raja S, Massey JM, Juel VC, Shin J, Hobson-Webb LD, Gable K, Guptill JT. Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis. Exp Neurol. 2020 Mar;325:113146.
Published In
Exp Neurol
DOI
EISSN
1090-2430
Publication Date
March 2020
Volume
325
Start / End Page
113146
Location
United States
Related Subject Headings
- Th17 Cells
- Receptors, Cholinergic
- Nuclear Receptor Subfamily 1, Group F, Member 3
- Neurology & Neurosurgery
- Myasthenia Gravis
- Middle Aged
- Male
- Interleukin-17
- Immunologic Factors
- Humans