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Dynamic perfluorinated gas MRI reveals abnormal ventilation despite normal FEV1 in cystic fibrosis.

Publication ,  Journal Article
Goralski, JL; Chung, SH; Glass, TM; Ceppe, AS; Akinnagbe-Zusterzeel, EO; Trimble, AT; Boucher, RC; Soher, BJ; Charles, HC; Donaldson, SH; Lee, YZ
Published in: JCI Insight
January 30, 2020

We hypothesized that dynamic perfluorinated gas MRI would sensitively detect mild cystic fibrosis (CF) lung disease. This cross-sectional study enrolled 20 healthy volunteers and 24 stable subjects with CF, including a subgroup of subjects with normal forced expiratory volume in the first second (FEV1; >80% predicted, n = 9). Dynamic fluorine-19-enhanced MRI (19F MRI) were acquired during sequential breath holds while breathing perfluoropropane (PFP) and during gas wash-out. Outcomes included the fraction of lung without significant ventilation (ventilation defect percent, VDP) and time constants that described PFP wash-in and wash-out kinetics. VDP values (mean ± SD) of healthy controls (3.87% ± 2.7%) were statistically different from moderate CF subjects (19.5% ± 15.5%, P = 0.001) but not from mild CF subjects (10.4% ± 9.9%, P = 0.24). In contrast, the fractional lung volume with slow gas wash-out was elevated both in subjects with mild (9.61% ± 4.87%; P = 0.0066) and moderate CF (16.01% ± 5.01%; P = 0.0002) when compared with healthy controls (3.84% ± 2.16%) and distinguished mild from moderate CF (P = 0.006). 19F MRI detected significant ventilation abnormalities in subjects with CF. The ability of gas wash-out kinetics to distinguish between healthy and mild CF lung disease subjects makes 19F MRI a potentially valuable method for the characterization of early lung disease in CF. This study has been registered at ClinicalTrials.gov (NCT03489590).

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Published In

JCI Insight

DOI

EISSN

2379-3708

Publication Date

January 30, 2020

Volume

5

Issue

2

Location

United States

Related Subject Headings

  • Young Adult
  • Ventilation
  • Transcription Factors
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Lung
  • Kinetics
  • Humans
  • Fluorocarbons
 

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Goralski, J. L., Chung, S. H., Glass, T. M., Ceppe, A. S., Akinnagbe-Zusterzeel, E. O., Trimble, A. T., … Lee, Y. Z. (2020). Dynamic perfluorinated gas MRI reveals abnormal ventilation despite normal FEV1 in cystic fibrosis. JCI Insight, 5(2). https://doi.org/10.1172/jci.insight.133400
Goralski, Jennifer L., Sang Hun Chung, Tyler M. Glass, Agathe S. Ceppe, Esther O. Akinnagbe-Zusterzeel, Aaron T. Trimble, Richard C. Boucher, et al. “Dynamic perfluorinated gas MRI reveals abnormal ventilation despite normal FEV1 in cystic fibrosis.JCI Insight 5, no. 2 (January 30, 2020). https://doi.org/10.1172/jci.insight.133400.
Goralski JL, Chung SH, Glass TM, Ceppe AS, Akinnagbe-Zusterzeel EO, Trimble AT, et al. Dynamic perfluorinated gas MRI reveals abnormal ventilation despite normal FEV1 in cystic fibrosis. JCI Insight. 2020 Jan 30;5(2).
Goralski, Jennifer L., et al. “Dynamic perfluorinated gas MRI reveals abnormal ventilation despite normal FEV1 in cystic fibrosis.JCI Insight, vol. 5, no. 2, Jan. 2020. Pubmed, doi:10.1172/jci.insight.133400.
Goralski JL, Chung SH, Glass TM, Ceppe AS, Akinnagbe-Zusterzeel EO, Trimble AT, Boucher RC, Soher BJ, Charles HC, Donaldson SH, Lee YZ. Dynamic perfluorinated gas MRI reveals abnormal ventilation despite normal FEV1 in cystic fibrosis. JCI Insight. 2020 Jan 30;5(2).

Published In

JCI Insight

DOI

EISSN

2379-3708

Publication Date

January 30, 2020

Volume

5

Issue

2

Location

United States

Related Subject Headings

  • Young Adult
  • Ventilation
  • Transcription Factors
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Lung
  • Kinetics
  • Humans
  • Fluorocarbons