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Comparison of wide-field swept source optical coherence tomography angiography and fundus autofluorescence in tubercular serpiginous-like choroiditis.

Publication ,  Journal Article
Brar, M; Sharma, M; Grewal, SPS; Grewal, DS
Published in: Indian J Ophthalmol
January 2020

PURPOSE: To evaluate the potential clinical utility of wide-field swept source optical coherence tomography angiography (SS-OCTA) using a prototype device compared to a wide-field fundus autofluorescence (FAF) for analysis of the disease activity in eyes with tubercular serpiginous-like choroiditis (TBSLC). METHODS: Using a prototype SS-OCTA device (PLEX Elite, Carl Zeiss Meditec, Dublin, CA), 17 eyes of 12 consecutive patients with TBSLC were imaged and multiple 12 mm × 12 mm OCTA scans were captured, which were montaged to create wide-field montage OCTA images scans. A wide- FAF (Eidon, CenterVue, Padova, Italy) was performed in the same sitting. Two masked graders independently analyzed OCTA and FAF images for the presence of choroidal lesions, recorded the number of lesions identifiable, and provided a subjective grading for the activity of individual lesion, which were then compared. RESULTS: The total number of lesions identified on FAF were 282 (posterior pole lesions, n = 129 and peripheral lesions n = 153) and on wide-field SS-OCTA were 230 (posterior pole lesions, n = 108 and peripheral lesions n = 122). Active choroidal lesions were comparable on the two machines (n = 28 on FAF and n = 28 on SS-OCTA, respectively); whereas numerous healed lesions were identified on FAF (n = 219) as compared to SS-OCTA (n = 170). There was good correlation among the devices for healed lesions (Pearson correlation, r = 0.82) and active lesions (r = 0.88). CONCLUSION: There was good correlation between FAF and wide-field SS-OCTA for detection of disease activity in TBSLC; however, FAF depicted greater number of healed lesions compared to wide-field SS-OCTA.

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Published In

Indian J Ophthalmol

DOI

EISSN

1998-3689

Publication Date

January 2020

Volume

68

Issue

1

Start / End Page

106 / 211

Location

India

Related Subject Headings

  • White Dot Syndromes
  • Visual Acuity
  • Tuberculosis, Ocular
  • Tomography, Optical Coherence
  • Retrospective Studies
  • Retinal Vessels
  • Ophthalmology & Optometry
  • Humans
  • Fundus Oculi
  • Fluorescein Angiography
 

Citation

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Brar, M., Sharma, M., Grewal, S. P. S., & Grewal, D. S. (2020). Comparison of wide-field swept source optical coherence tomography angiography and fundus autofluorescence in tubercular serpiginous-like choroiditis. Indian J Ophthalmol, 68(1), 106–211. https://doi.org/10.4103/ijo.IJO_78_19
Brar, Manpreet, Mansi Sharma, S. P. S. Grewal, and Dilraj S. Grewal. “Comparison of wide-field swept source optical coherence tomography angiography and fundus autofluorescence in tubercular serpiginous-like choroiditis.Indian J Ophthalmol 68, no. 1 (January 2020): 106–211. https://doi.org/10.4103/ijo.IJO_78_19.
Brar, Manpreet, et al. “Comparison of wide-field swept source optical coherence tomography angiography and fundus autofluorescence in tubercular serpiginous-like choroiditis.Indian J Ophthalmol, vol. 68, no. 1, Jan. 2020, pp. 106–211. Pubmed, doi:10.4103/ijo.IJO_78_19.

Published In

Indian J Ophthalmol

DOI

EISSN

1998-3689

Publication Date

January 2020

Volume

68

Issue

1

Start / End Page

106 / 211

Location

India

Related Subject Headings

  • White Dot Syndromes
  • Visual Acuity
  • Tuberculosis, Ocular
  • Tomography, Optical Coherence
  • Retrospective Studies
  • Retinal Vessels
  • Ophthalmology & Optometry
  • Humans
  • Fundus Oculi
  • Fluorescein Angiography